ACTRN12619000121167CompletedPhase 2
Effect of exogenous vitamin B1 (thiamine) administration on blood lactate concentrations in enterally-fed, critically ill patients with hypophosphatemia
Conditions
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- Royal Melbourne Hospital
- Enrollment
- 90
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
- Allocation
- Randomised controlled trial
- Primary Purpose
- Treatment
- Masking
- Open (masking not used)
Eligibility Criteria
- Ages
- 18 Years to o limit (—)
- Sex
- All
Inclusion Criteria
- •Critically ill patient admitted to the ICU
- •Receiving enteral nutrition (EN) for <= 72 hours in this ICU admission
- •A serum phosphate <= 0.65mmol./L in the last 24 hours while receiving EN
Exclusion Criteria
- •Patients who have received >= 100mg of intravenous (IV) thiamine in the previous 48 hours
- •Patient is anticipated to be discharged from the ICU today or tomorrow
- •Treating clinician believes that either treatment (to receive or not to receive IV thiamine) is in the best interest of the patient
- •Aged < 18 years
- •Patients with a known or suspected hypersensitivity to thiamine
- •Patients receiving palliative care
- •Pregnancy
- •Patients admitted for consideration of organ donation
- •Patients previously enrolled in this trial
- •Patients with a known latex allergy
- •Patients with documented or suspected acute beri-beri disease
- •Patients with documented or suspected acute Wernicke's encephalopathy
Investigators
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