The Effect of Cognitive Enhancement as a Precursor to Computer Based Training for Cognitive Behavioral Therapy (CBT4CBT)
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 99
- 试验地点
- 2
- 主要终点
- Reduction in cocaine use
研究概览
简要总结
The investigators are conducting a randomized clinical trial of rapid abstinence initiation and cognitive control training as a precursor to our new web-based version of the CBT4CBT (Computer Based Training for Cognitive Behavioral Therapy) program to evaluate its effectiveness relative to standard outpatient counseling at the Midwestern Connecticut Council of Alcoholism (MCCA). CCT will be used to assess attention, working memory and inhibitory control and the computer-based training program (CBT4CBT) focuses on teaching basic coping skills, presenting examples of effective use of coping skills in a number of realistic situations in video form, and providing opportunities for patients to practice and review new skills while receiving cocaine abuse treatment.
详细描述
150 cocaine dependent individuals will be randomly assigned to one of 3 conditions delivered over 4 weeks in the context of intensive outpatient treatment. 1. Treatment as Usual (TAU), 2. rapid abstinence initiation (RAI) or 3. computerized cognitive control training with escalating reinforcement for improved performance on training tasks (CCT). All participants will then receive an 8 week trial of CBT4CBT in addition to TAU. Follow up evaluation thru 6 months posttreatment will assess durability and delayed emergence of treatment effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years of age or older
- •Meet current DSM-5 criteria for cocaine use disorder
- •Are sufficiently stable for 12 weeks of outpatient treatment
- •Are willing to provide locator information for follow-up
- •Are fluent in English
- •Have a 6th grade or higher reading level for completion of assessments
排除标准
- •Untreated bipolar or schizophrenic disorder
- •Current suicide risk
- •Have a legal case pending such that incarceration during the 12-week protocol is likely
- •Are physically dependent on alcohol, opioids or benzodiazepines and require detoxification
研究组 & 干预措施
TAU plus Rapid Abstinence Initiation (RAI)
Treatment normally offered at this clinic which could include individual or group drug counseling sessions three times per week lasting three hours each time PLUS the chance to earn money for urine specimens that are negative for cocaine during the first 4 weeks of treatment
干预措施: TAU plus Rapid Abstinence Initiation (RAI) (Behavioral)
TAU plus RAI plus Cognitive Control Training (CCT)
Treatment normally offered at this clinic which could include individual or group drug counseling sessions three times per week lasting three hours each time PLUS the chance to earn money for urine specimens that are negative for cocaine during the first 4 weeks of treatment PLUS sessions of computerized games 3 times per week for the first 4 weeks.
干预措施: TAU plus Rapid Abstinence Initiation (RAI) (Behavioral)
TAU plus RAI plus Cognitive Control Training (CCT)
Treatment normally offered at this clinic which could include individual or group drug counseling sessions three times per week lasting three hours each time PLUS the chance to earn money for urine specimens that are negative for cocaine during the first 4 weeks of treatment PLUS sessions of computerized games 3 times per week for the first 4 weeks.
干预措施: TAU plus RAI plus Cognitive Control Training (CCT) (Behavioral)
TAU plus RAI plus Cognitive Control Training (CCT)
Treatment normally offered at this clinic which could include individual or group drug counseling sessions three times per week lasting three hours each time PLUS the chance to earn money for urine specimens that are negative for cocaine during the first 4 weeks of treatment PLUS sessions of computerized games 3 times per week for the first 4 weeks.
干预措施: Treatment As Usual (TAU) (Behavioral)
TAU plus Rapid Abstinence Initiation (RAI)
Treatment normally offered at this clinic which could include individual or group drug counseling sessions three times per week lasting three hours each time PLUS the chance to earn money for urine specimens that are negative for cocaine during the first 4 weeks of treatment
干预措施: Treatment As Usual (TAU) (Behavioral)
Treatment As Usual (TAU)
Treatment normally offered at this clinic which could include individual or group drug counseling sessions three times per week lasting three hours each time.
干预措施: Treatment As Usual (TAU) (Behavioral)
结局指标
主要结局
Reduction in cocaine use
时间窗: 12 weeks
Using urine and breathalyzer screening for negative cocaine and alcohol testing.
次要结局
- Subjects ability to demonstrate coping skills acquisition through a computerized role-playing evaluation(12 weeks)