The Effect of Roux-en-Y Gastric Bypass on Mitochondrial Function in Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
研究概览
简要总结
Roux-en-Y gastric bypass (RYGB) surgery induces resolution of type 2 diabetes, often within days after surgery and before significant weight loss. The aim of this study is to investigate whether changes in mitochondrial function contributes to the early improvement of type 2 diabetes after RYGB.
详细描述
Mitochondrial dysfunction has been linked to development of insulin resistance in the muscle and hence to the pathogenesis of type 2 diabetes. Mitochondrial function can be studied non-invasively by 31 Phosphor Magnetic Resonance spectroscopy (31PMRS). In this study we will investigate changes in mitochondrial function using the combination of 31 PMRS and Near Infra-Red Spectroscopy (NIRS) after gastric bypass.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients eligible for gastric bypass surgery or cholecystectomy
- •Verified type 2 diabetes or normal glucose tolerance by OGTT
排除标准
- •Patients unable to fit the dimensions of the MRI-scanner
研究者
Anna Kirstine Bojsen-Moeller
MD
Hvidovre University Hospital