Development and Validation of a Survival Prediction Model for Esophageal Cancer Patients After Esophagectomy

Completed

• Conditions: Survivorship
• Interventions: Other: This was an observational study without any intervention

• Registration Number: NCT06169930
• Lead Sponsor: Yongtao Han

Brief Summary

In this retrospective study, we analyzed data from the Sichuan Cancer Hospital \& Institute Esophageal Cancer Case Management Database (SCH-ECCM Database) from January 2010 to December 2017. Our study focused on examining the clinicopathological characteristics, lymph node removal at each station, and treatment details of patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy. Using this data, we developed a prediction model for OS by considering a combination of clinical characteristics and details of lymphadenectomy variables.

Detailed Description

In this retrospective study, we analyzed data from the Sichuan Cancer Hospital \& Institute Esophageal Cancer Case Management Database (SCH-ECCM Database) from January 2010 to December 2017. Our study focused on examining the clinicopathological characteristics, lymph node removal at each station, and treatment details of patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy. Using this data, we developed a prediction model for OS by considering a combination of clinical characteristics and details of lymphadenectomy variables. Additionally, the receiver operating characteristic curve demonstrated an area under the curve greater than 0.7 at 1, 3, and 5 years in both the verification and training groups. Furthermore, Kaplan-Meier (K-M) curves showed that our model effectively distinguished between high- and low-risk groups (p \< 0.01).

Study Timeline

• Status Verified: 2023-12
• Study Start: 2023-12-01
• Primary Completion: 2023-12-01
• Study Completion: 2023-12-01
• Study First Submitted: 2023-12-03
• Study First Submitted QC: 2023-12-13
• Last Update Submitted: 2023-12-13
• Study First Posted: 2023-12-14
• Last Update Posted: 2023-12-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2957

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
low-risk	This was an observational study without any intervention	-
high-risk	This was an observational study without any intervention	-

Primary Outcome Measures

Name	Time	Method
Survival	April 2022-April 2024	Overall survival (OS) was defined as the time from the month and year of surgery until death or the last follow-up in April 2022.

Trial Locations

Locations (1)

Sichuan Cancer Hospital and Research Institute; 🇨🇳 Chengdu, Sichuan, China