Mapatumumab, Cisplatin and Radiotherapy for Advanced Cervical Cancer

Phase 1

Completed

• Conditions: Advanced Cervical Cancer
• Interventions: Drug: mapatumumab; Drug: cisplatin; Radiation: radiotherapy

• Registration Number: NCT01088347
• Lead Sponsor: University Medical Center Groningen

Brief Summary

Chemoradiotherapy has become the standard of care for women with locally advanced cervical cancer. The available data support a 30 to 50% reduction in the risk of death from cervical cancer for women with locally advanced disease undergoing radiotherapy (RT) and concomitant cisplatin-based chemotherapy compared to RT alone. Despite the fact that this is currently the best treatment of locally advanced cervical cancer, 5-year overall survival is still only 52%.

The fully human, agonist monoclonal antibody mapatumumab binds to the Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptor 1 (TRAIL-R1, DR4) and induces cytotoxicity in multiple tumor cell lines in vitro and in vivo. In multiple phase I and phase II studies, mapatumumab appeared to be safe both as single agent and in combination with chemotherapy, including cisplatin.

In cervical cancer cell lines, mapatumumab induced apoptosis in 51% of the cells. Mapatumumab in combination with irradiation increased apoptosis to 83%.

In this phase 1b/2 study, the investigators will evaluate the safety, tolerability and efficacy of mapatumumab in combination with cisplatin and radiotherapy in patients with locally advanced cervical cancer.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-03
• Study First Submitted: 2010-03-10
• Study First Submitted QC: 2010-03-16
• Study First Posted: 2010-03-17
• Primary Completion: 2014-03
• Study Completion: 2014-03
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-17
• Last Update Posted: 2024-04-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 9

Inclusion Criteria

1. Patients with histologically or cytologically confirmed stage IB2, IIA2, IIB, III, and IVA cervical cancer, according to the FIGO classification

2. Adequate bone marrow, renal and liver function:

   • Absolute neutrophil count ≥ 1.5 x 109 /L.
   • Platelet count ≥ 100 x 109 /L.
   • Serum creatinine level ≤ 1.5 x upper limit of normal (ULN).
   • Total bilirubin < 1.25 x ULN.
   • Aspartate transaminase (AST) and alanine transaminase (ALT) ≤ 2.5 x ULN.

3. Performance status of 0 to 1 on the Eastern Cooperative Oncology Group (ECOG) Scale.

4. Age 18 years or older.

5. Life expectancy of ≥ 12 weeks.

6. Have the ability to understand the requirements of the study, provide written informed consent (including consent for the use and disclosure of research-related health information), and comply with the study and follow-up procedures.

Exclusion Criteria

1. Any co-morbid condition that in the judgment of the investigator renders the subject at high risk of treatment complications or reduces the possibility of assessing clinical effect.
2. Cytotoxic agent, hormonal therapy, or radiation therapy within 3 weeks (6 weeks for nitrosoureas or mitomycin-C) prior to day 1, cycle 1; investigational agent within 4 weeks prior to day 1, cycle 1.
3. Need for concomitant anticancer therapy (surgery, radiation therapy, chemotherapy, immunotherapy, radiofrequency ablation) or other investigational agents during the study treatment period.
4. Major surgery within 4 weeks before enrollment; minor surgery (except for insertion of vascular access device) within 2 weeks before enrollment; or not yet recovered from the effects of the surgery.
5. Systemic steroids within 1 week before enrollment except steroids used as part of an antiemetic regimen or maintenance-dose steroids for non-cancerous disease.
6. History of any infection requiring hospitalization or antibiotics within 2 weeks before enrollment.
7. Known brain or spinal cord metastases unless adequately treated (surgery or radiotherapy) with no evidence of progression and neurologically stable off anticonvulsants and steroids.
8. Known human immunodeficiency virus infection.
9. Unstable angina, myocardial infarction, cerebrovascular accident, > Class II congestive heart failure according to the New York Heart Association Classification for Congestive Heart Failure within 6 months before enrollment.
10. Pregnant female or nursing mother.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Advanced cervical cancer patients	mapatumumab	-
Advanced cervical cancer patients	cisplatin	-
Advanced cervical cancer patients	radiotherapy	-

Primary Outcome Measures

Name	Time	Method
Phase 1b: safety and tolerability of mapatumumab in combination with cisplatin and radiotherapy Phase 2: efficacy of mapatumumab in combination with cisplatin and radiotherapy	5 months	Phase 2: pathological complete response rate

Secondary Outcome Measures

Name	Time	Method
Disease free survival, overall survival	From enrollment until recurrence of disease, from enrollment until death
Apoptotic pathway biomarkers, PK parameters	During the study, until 5 months after enrollment

Trial Locations

Locations (1)

University Medical Center Groningen; 🇳🇱 Groningen, Netherlands