NCT03543267已完成不适用
Feasibility Study on Neurocognitive Plasticity in Patients With Focal and Drug-resistant Epilepsy, Before and After Surgery. Evaluation by Functional and Anatomic Neuroimaging
University Hospital, Grenoble2 个研究点 分布在 1 个国家目标入组 37 人开始时间: 2017年10月21日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- to define anatomo-functional reorganization (plasticity) profiles by functional MRI for the mentioned cognitive functions, before surgery (chronic plasticity induced by the epileptogenic zone) in patients with drug-resistant epilepsy.
研究概览
简要总结
This study consist of define anatomo-functional reorganization (plasticity) profiles for the mentioned cognitive functions, before surgery (chronic plasticity induced by the epileptogenic zone) in patients with drug-resistant epilepsy.
For that, patients will have 2 MRI examinations, one before surgery and the second, between 3 and 8 months after surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with diagnosis of pharmaco-resistant focal epilepsy
- •Patient candidate for surgery to resect the epileptogenic zone
- •Patients affiliated to a social security scheme or beneficiaries of such a scheme
- •Patients with French as their mother tongue
- •Patients who have given signed informed consent before performing any procedure related to the study.
排除标准
- •Contraindication to performing an MRI:
- •Intellectual disability objectified by a Mini Mental Score (MMS) score <24 in the year preceding inclusion,
- •Existence of a severe condition in general: cardiac, respiratory, hematological, renal, hepatic, cancerous,
- •Participation in other research protocols underway with exclusion period or in the previous week,
- •Persons referred to in Articles L1121-5 to L1121-8 of the Public Health Code.
结局指标
主要结局
to define anatomo-functional reorganization (plasticity) profiles by functional MRI for the mentioned cognitive functions, before surgery (chronic plasticity induced by the epileptogenic zone) in patients with drug-resistant epilepsy.
时间窗: One hour and thirty minutes
The outcome measure is the hemispheric lateralization index (IL) before surgery measured by functional MRI
次要结局
未报告次要终点
研究者
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Neuroplasticity in TBI and SchizophreniaTraumatic Brain InjurySchizophreniaNCT03995368VA Office of Research and Development72
已完成
不适用
TMS for the Investigation of Brain Plasticity in Autism Spectrum DisordersAutism Spectrum DisorderIntellectual DisabilityNCT02836405Boston Children's Hospital164
已完成
不适用
Behavior, Neuropsychology, Neuroimage and Electrophysiology in Autistic Individuals With and Without CNVsAutismNCT01582256National Taiwan University Hospital132
招募中
不适用
Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve RepairHand TransplantationPeripheral Nerve InjuriesNeurologic RehabilitationNCT03610763University of Missouri-Columbia180
终止
不适用
Modulation and Assessment of Mental Flexibility in Dysexecutive Brain PatientsDysexecutive SyndromeNCT04253522University Hospital, Toulouse16