The Impact of the SCN9A Gene Polymorphism on Postoperative Pain
Completed
- Conditions
- Pain, PostoperativePregnancy
- Registration Number
- NCT02496455
- Lead Sponsor
- Tokat Gaziosmanpasa University
- Brief Summary
The purpose of this study to determine the association between postoperative pain after cesarean section and several single nucleotide polymorphisms in SCN9A sodium channels gene.
- Detailed Description
SCN9A gene encodes an alpha subunit of the voltage-gated sodium channel (Nav1.7) and polymorphisms of this gene are associated with severe pain disorders. The impact of the polymorphisms in SCN9A on postoperative pain and opioid consumption after cesarean section is unclear.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 200
Inclusion Criteria
- The women aged 18 to 45,
- in 36 to 40 weeks of pregnancy
- undergoing cesarean section
Exclusion Criteria
- History of chronic pain or pain disorders
- Psychiatric diseases
- Diabetes mellitus
- Severe cardiovascular, kidney or liver diseases
- Alcohol or drug abuse
- Heavy smoker
- Unable to use the Patient controlled analgesia (PCA) pump
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain up to postoperative 24 hours The pain will be evaluated with the visual analog scale
- Secondary Outcome Measures
Name Time Method Opioid consumption Up to postoperative 24 hours The total amount of the tramadol administered to the patient will be recorded
Trial Locations
- Locations (1)
Gaziosmanpasa University Medical School Hospital
🇹🇷Tokat, Turkey
Gaziosmanpasa University Medical School Hospital🇹🇷Tokat, Turkey