Role of Xanthophylls in Visual Function
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 48
- 主要终点
- evolution of MPOD Baseline Vs M6
研究概览
简要总结
Ecy of lutein supplementation alone, or zeaxanthin supplementation alone, or a combination of both, compared to placebo, on the evolution of macular pigment density (MPOD) measured by fundus photography in XANTH-deficient patients receiving enteral nutrition.
详细描述
Lutein and zeaxanthin are plant pigments belonging to the carotenoid family, and more precisely to the subfamily of xanthophylls (XANTH), which are oxygenated carotenoids. These phytochemicals are not synthesised by humans and are almost always present in our diet. They are significantly absorbed and transported in our body. They are present in various organs, e.g. the eye and the skin. They accumulate in very high concentrations in the central area of the human retina. Because of this high accumulation, it has been hypothesised that they play one or more specific roles in the eye. This has been confirmed by several studies which have shown that XANTHs are involved in protecting the eye from damage by certain light rays (blue) and age-related macular degeneration. Other studies suggest that XANTH may improve glare tolerance and contrast sensitivity. They may also improve sensitivity to red and green colour discrimination. However, identifying the exact relationship between XANTH and visual function in XANTH supplementation is complicated by two main problems. Firstly, XANTH supplementation does not always increase MPOD (Macular Pigment Optical Density), which is an indicator of the concentration of XANTH in the macula, because there are poor responders to XANTH, i.e. subjects who absorb it very poorly and/or transport it very poorly to the retina. Secondly, MPOD seems to reach a maximum value and a plateau, and increasing the dose of XANTH, or the duration of supplementation, does not increase MPOD further. This is particularly the case in individuals who already have a high MPOD, close to the maximum value, before supplementation because they often consume XANTH-rich foods, and/or because they are strong responders to XANTH. Therefore, although studies suggest a specific role for XANTH in visual function, the problem of initially high MPOD in some individuals, coupled with MPOD saturation, has not allowed previous studies to provide definitive evidence on their role(s) in visual function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •On exclusive enteral nutrition for at least 6 months
- •Exclusive enteral nutrition that is intended to be continued for at least 6 more months.
- •No XANTH supplementation in the last 6 months.
- •Able to sit up to allow visual examinations to be performed
- •Sufficient understanding to perform visual examinations, at the discretion of the physician
- •Written consent signed by the patient or agreement of their carer, trusted person, relative, family for patients with cognitive impairment (assessed using an MMS test). A patient with an MMSE test result ≤ 24 will be considered as having cognitive disorders.
排除标准
- •Current treatment with hydroxychloroquine or any other drug known to cause ocular toxicity
- •Visually impaired patient: patient unable to read text (font size 11) at close range, with visual correction if the patient usually wears it
- •Unoperated cataracts in both eyes
- •Pregnant or breastfeeding woman
- •Patient under legal protection: guardianship or curatorship
- •Participation in other research in the same field of dietary supplementation, which may interfere with the results of this research.
- •Secondary exclusion criteria :
- •Absence of XANTH (lutein and zeaxanthin) deficiency* in the blood sample taken at inclusion.
- •Physical, ophthalmological or cognitive characteristics, evaluated at the Quinze-Vingt ophthalmological examination, which do not allow a reliable measurement of MPOD or of all the settings of visual function.
结局指标
主要结局
evolution of MPOD Baseline Vs M6
时间窗: Baseline, month 6
Changes in MPOD by fundus photography (blue light autofluorescence) from baseline to 6 months of supplementation (M6) with lutein or zeaxanthin, or a combination of both, vs placebo.
次要结局
- Measurement of visual accuity and settings(Baseline, Month 4, Month 7, Month 13(option))
- Linkage between MPDO and visual settings(Baseline, Month 6)
- Linkage between MPOD and blood and xanth blodd count(Baseline, Month 4 and Month 13(option))