Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery
- Conditions
- Arteriovenous Malformation
- Interventions
- Registration Number
- NCT02552459
- Lead Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
- Brief Summary
The purpose of this study is to determine effect of combined medication of sufentanil and dexmedetomidine in patient controlled analgesia after neurosurgery.
- Detailed Description
Sufentanil is a classical drug for postoperative analgesia. Dexmedetomidine is a commonly used α2-adrenergic receptor, and it helps provide sedation, analgesia and inhibition of sympathetic activation. The investigators propose to recruit 120 patients who is undergoing the arteriovenous malformation embolism operation in department of Neurosurgery. Patients will be randomly divided into 4 groups(control group, sufentanil and low dexmedetomidine dose group, sufentanil and middle dexmedetomidine dose group, sufentanil and high dexmedetomidine dose group), then the investigators select post-operative records to determine whether dexmedetomidine can take a positive role in neurosurgical analgesia.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 120
- patients undergoing venous malformation embolization operation through general anesthesia.
- aged 18-65 years old.
- operating time varies 1-4h,and extubation after the operation.
- long-term use of analgesics,sedatives or non steroidal anti-inflammatory drugs history.
- known for dexmedetomidine or other drugs allergy in this study.
- cannot communicate.
- preoperative systolic blood pressure <90 mmHg, or the heart rate <50/min.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description sufentanil&dexmedetomidine 1 dexmedetomidine 1 sufentanil 150μg，dexmedetomidine 0.05μg/kg/h，intravenous administration during the following 72 hours after operation. sufentani&dexmedetomidine 2 dexmedetomidine 2 sufentanil 150μg，dexmedetomidine 0.1μg/kg/h，intravenous administration during the following 72 hours after operation. sufentanil&dexmedetomidine 3 dexmedetomidine 3 sufentanil 150μg，dexmedetomidine 0.15μg/kg/h ，intravenous administration during the following 72 hours after operation. sufentanil Sufentanil sufentanil 150μg，intravenous administration during the following 72 hours after operation. sufentani&dexmedetomidine 2 Sufentanil sufentanil 150μg，dexmedetomidine 0.1μg/kg/h，intravenous administration during the following 72 hours after operation. sufentanil&dexmedetomidine 1 Sufentanil sufentanil 150μg，dexmedetomidine 0.05μg/kg/h，intravenous administration during the following 72 hours after operation. sufentanil&dexmedetomidine 3 Sufentanil sufentanil 150μg，dexmedetomidine 0.15μg/kg/h ，intravenous administration during the following 72 hours after operation.
- Primary Outcome Measures
Name Time Method Pain on the VAS scale within the following 72 hours after surgery measure the VAS score at pre-operative day and post-operative 4h、8h、12h、24h、48h、72h。
- Secondary Outcome Measures
Name Time Method blood pressure(BP)(mmHg) within the following 72 hours after surgery measure BP(mmHg),HR (/min),spO2(%), and breath(/min),on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
heart rate(HR) (/min) within the following 72 hours after surgery measure BP(mmHg),HR (/min),spO2(%), and breath(/min),on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
spO2(%) within the following 72 hours after surgery measure BP(mmHg),HR (/min),spO2(%), and breath(/min),on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
breath(/min) within the following 72 hours after surgery measure BP(mmHg),HR (/min),spO2(%), and breath(/min),on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
sedation level on ramsay sedation score within the following 72 hours after surgery measure sedation level using ramsay sedation score on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
vomit times within the following 72 hours after surgery measure vomit times on pre-operative day and at measure sedation level using ramsay sedation score on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
nausea within the following 72 hours after surgery measure whether nausea exists on pre-operative day and at measure sedation level using ramsay sedation score on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
Trial Locations
- Locations (1)
the First Affiliated Hospital of Sun Yetsen University
🇨🇳Guangzhou, Guangdong, China