Effect of L-Arginine supplementation on antioxidant status in Pre-diabetic patients .

Phase 2

Conditions: pre-diabetic patient.
Impaired glucose tolerancePrediabetes

Registration Number: IRCT201211106415N2

Lead Sponsor: Vice chancellor for research,Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 46

Inclusion Criteria

A)
- tendency to cooperate with research project
- Newly diagnosed individuals with pre-diabetes
- People with pre-diabetes, a fasting blood sugar of 100 -125mg/ dL or a two-hour blood sugar between 140 to 199 mg/ dL
- Range of BMI 25 to 34.9 Kg / m 2
- Age: 20 to 50 years;
B) Not allowed to inter criteria: - Have not past medical history of chronic diseases such as cardiovascular disease, liver disease, thyroid disease, chronic infection, heart attack or stroke in the previous years .- Taking lipid-lowering drugs, blood sugar-lowering drugs, estrogen or progesterone, antibiotics during past year ,- Taking any supplements such as L - arginine during the 2 months prior to the study- Smoking - pregnancy or lactation, or menopause - alcohol intake;
C)

Exclusion Criteria

- Non-compliance supplements taking (more than 10% of supplements it is not been taken .)
- The existence of any of the criteria Not allowed to inter criteria - not wanting to continued cooperation

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glutathione peroxidase activity level. Timepoint: Before and 2 months after the start of supplementation. Method of measurement: Blood testing (by ELISA kit).;Glutathione reductase activity. Timepoint: Before and 2 months after the start of supplementation. Method of measurement: Blood testing (by ELISA kit).;Superoxide dismutase activity. Timepoint: Before and 2 months after the start of supplementation. Method of measurement: Blood testing (by ELISA kit).;Total antioxidant capacity. Timepoint: Before and 2 months after the start of supplementation. Method of measurement: Blood testing (by ELISA kit).

Secondary Outcome Measures