Deep brain stimulation in idiopathic dystonia: clinical characterisation of a cohort of patients with therapeutic failure of GPi-DBS

• Conditions: insufficient response to deep brain stimulation of the internal part of the globus pallidus; G24.1; Idiopathic familial dystonia

• Registration Number: DRKS00003105
• Lead Sponsor: Klinik und Poliklinik fuer NeurologieUniklinik KölnMedizinische Fakultaet der Universitaet zu Koeln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-07-11
• Study Completion: 2015-07-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

age between 18-85 years
- diagnosis of idiopathic dystonia at time of surgery
- bilateral GPI-DBS
- poor response to GPI-DBS (less than 30 % improvement on the BFMDRS-M compared to preoperative state)
- stable clinical status after GPi-DBS for a minimum of 3 months
- written informed consent given by patient
- no other severe neurological or other clinical problem

Exclusion Criteria

- other severe neurological disease (dementia, epilepsy)
- persons who are not legally competent, minors and indivduals who have been under custody due to a court ruling or by decision of public authorities

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cross-sectional study: examination of patients with poor therapeutic response to GPi-DBS (Globus Pallidus internus- deep brain stimulation), clinical characterisation of this patient cohort with re-evaluation of initial diagnosis at time of surgery, classification into groups with putative causes of therapeutic failure, evaluation of frequencies of symptoms and findings in this cohort