Assessment the Role of Tranexamic Acid in Prevention of Postpartum Hemorrhage”

Not Applicable

• Conditions: Haematological Disorders; Pregnancy and Childbirth; postpartum hemorrhage; Anaesthesia

• Registration Number: PACTR202102576748863
• Lead Sponsor: Faculty of medicine Ain Shams University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-02-05
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

Singleton pregnancy, P1-CS (previous one section after failed consent for trial of labor after CS), Term = 37 weeks of gestation , Elective cesarean section, spinal anesthesia and written Informed consent.

Exclusion Criteria

Failed spinal anesthesia (more than 2 attempts), Multiple pregnancy, Grand multipara, Placenta previa, Abruptio placentae, Polyhydraminos, Fever, Rupture of membranes, Patients on anticoagulants or antiplatelets, History of eclampsia or pre-eclampsia in current pregnancy, History of cardiovascular complications as Coronary artery disease or myocardial infarction, Repaired or unrepaired congenital heart disease, unstable arrhythmia or Congestive heart failure, or the patient had a contraindication to TXA administration as history of venous thromboembolism, active thromboembolic disease, high risk of thrombosis (e.g. factor V Leiden or protein C deficiency), allergy to TXA, Pre-existing hematuria or history of renal insufficiency

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome of our study is the amount of blood loss during and after CS; which was estimated by calculating the blood loss using standard equations by using preoperative and 24 hours postoperative hematocrit value as follows: <br>1.Estimate blood volume for women 65 ml/kg.<br>2.Estimate the red blood cell volume (RBCV) at the preoperative hematocrit (RBCVpreop).<br>3.Estimate RBCV at the postoperative hematocrit (RBCVpostop), assuming normal blood volume is maintained.<br>4.Calculate the RBCV lost: RBCVlost = RBCVpreop – RBCVpostop<br>5.Blood loss = RBCV lost × 3.<br>

Secondary Outcome Measures

Name	Time	Method
The secondary outcome measures were Vital signs (pulse, blood pressure, respiratory rate) during first 6 hours postoperatively and 24 hours post-operative hemoglobin and hematocrit values. Any complication that could be reported such as the need for blood transfusion or the need for any surgical measures to stop bleeding was recorded.