Outcomes of Pyeloplasty in Pediatric Patients With Differential Renal Function Less Than 10%
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Change in Differential Renal Function After Pyeloplasty
研究概览
简要总结
This study aims to evaluate the postoperative outcomes of pyeloplasty in pediatric patients presenting with ureteropelvic junction obstruction and preoperative differential renal function less than 10%, focusing on:
- Improvement or stabilization of renal function after surgery.
- Radiological improvement in hydronephrosis.
- Clinical outcomes such as symptom relief and complication rates.
详细描述
Ureteropelvic junction obstruction (UPJO) represents one of the most common causes of hydronephrosis in children.
Historically, kidneys with differential renal function (DRF) below 10% were considered non-salvageable, and nephrectomy was often recommended.
However, recent evidence suggests that pediatric renal units retain significant potential for recovery even when preoperative function is severely reduced.
Numerous studies over the past decade have demonstrated that pyeloplasty in low-functioning kidneys can result in functional improvement, stabilization, and significant symptomatic relief.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Month 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 1 month to 18 years.
- •Diagnosis of primary ureteropelvic junction obstruction.
- •Preoperative differential renal function <10% on MAG3 renogram.
- •A normal contralateral kidney.
排除标准
- •Secondary Ureteropelvic Junction Obstruction (UPJO) (postoperative, traumatic, or secondary to other anomalies).
- •Solitary functioning kidney.
- •Associated vesicoureteral reflux or posterior urethral valves.
- •Severe comorbidities affecting renal function.
- •Incomplete medical records.
研究组 & 干预措施
Study group
Patients with primary ureteropelvic junction obstruction.
干预措施: Pyeloplasty (Procedure)
结局指标
主要结局
Change in Differential Renal Function After Pyeloplasty
时间窗: 6 months after pyeloplasty
Differential renal function of the affected kidney will be assessed using MAG-3 diuretic renography. Renal function will be classified as improved when differential renal function increases by at least 5 percentage points, stable when the change is less than 5 percentage points in either direction, and deteriorated when it decreases by at least 5 percentage points.
次要结局
未报告次要终点
研究者
Yossof Hamed Abdul-Wanees Abdul-Qader
Resident of Urology, Faculty of Medicine, Tanta University, Egypt
Tanta University