The Acute Effects of Mitochondrial Antioxidant Supplementation on Metabolic Flexibility
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- Cardiorespiratory fitness
研究概览
简要总结
Study Purpose: To examine the acute effects of antioxidant supplementation on energy use during a single bout of exercise in apparently healthy adult men and women.
Specifically this study examined the acute effect of MitoQ on:
- cardiopulmonary responses to submax and maximal exercise
- Energy expenditure and fat/carbohydrate oxidation during sub maximal exercise.
In a double-blind, randomized, placebo controlled, cross-over study design, participants performed 2 experimental trials which differed only in the supplement consumed (MitoQ or Placebo). Participants performed identical exercise protocols which consisted of a series of submaximal workloads followed by a ramp protocol to volitional exhaustion.
详细描述
Participants performed the following 3 study visits:
Visit 1 consisted of baseline resting measures including blood pressure and blood vessel health, blood biomarkers, and body composition assessments.
Visits 2 and 3 were the acute supplementation intervention(s) with either MitoQ or Placebo in a randomly designed order. These visits included an assessment of blood pressure and blood vessel health and an exercise test on a stationary cycle. There was a minimum of 48-72 hours between trials 2 and 3.
Visit 1
- Participants arrived at the laboratory fasted from all food and drink other than water for at least 12 hours. The following assessments were performed:
- Informed consent and health history questionnaire
- Resting heart rate, handgrip strength, and body composition
- Resting electrocardiogram (ECG)
- Blood biomarkers (Total cholesterol, HDL, LDL-C, and triglycerides as well as fasting blood glucose and HbA1c).
- Blood pressure
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Be greater than or equal to 18 years of age
- •Have a resting seated systolic blood pressure (SBP) of less than 160 mmHg and diastolic blood pressure (DBP) less than 100 mmHg
- •Nonsmoker
- •Body mass index (BMI) less than or equal to 35 kg/m2
- •Considered physically inactive defined as participating in <150 min/week of moderate physical activity or <75 minutes/week of vigorous activity (ACSM).
排除标准
- •participants that cannot complete the exercise protocol or have any signs/symptoms suggestive of cardiovascular or metabolic disease.
- •Individuals that are currently on beta blockers
- •diagnosed with type II diabetes will be excluded.
结局指标
主要结局
Cardiorespiratory fitness
时间窗: acutely (1 hr)
VO2max
次要结局
- Maximal Fat Oxidation rate(acutely (1hr))
- Ventilation(acutely (1hr))
- Blood pressure(acutely (1hr))
- Peak blood lactate(acutely (1hr))
- Heart rate(acutely (1 hr))