Examining Heart Attacks in Young Women
- Conditions
- Acute Myocardial Infarction
- Registration Number
- NCT00597922
- Lead Sponsor
- Yale University
- Brief Summary
Heart disease and heart attacks pose a serious health risk to young women, and women tend to experience less successful recoveries after a heart attack than men do. This study will examine various factors that may predispose women to heart attacks and to poor recovery after a heart attack. The differences between men and women in the medical care that they receive following a heart attack will also be studied.
- Detailed Description
Heart disease is one of the leading causes of death in women 55 years and younger, accounting for more than 8,000 deaths each year in the United States. Approximately 40,000 young women are hospitalized each year in the United States as a result of a heart attack. Research has shown that young women who have heart attacks are twice as likely to die in the hospital as young men who have heart attacks. While there has been an increase in awareness, little research has been conducted on understanding heart disease and heart attacks in young women. Specific biologic markers involved with inflammation, metabolic abnormalities, sex hormones, and genetics may indicate a predisposition to a heart attack and poor recovery. This study will analyze the biologic, demographic, psychosocial, environmental, and behavioral factors that may contribute to premature heart disease and to poor recovery after a heart attack in women. Researchers will examine if delays in receiving medical care following a heart attack can affect recovery and health outcomes for women. Gender differences in outcomes and the quality of medical care that is received following a heart attack will also be examined.
This study will enroll women and men who are hospitalized following a possible heart attack. At study entry, participants will be interviewed to collect information about symptoms, functioning, quality of life, and medical care. A medical record review will also occur. At 1 month after admission from the hospital, an interview will occur via phone and a blood sample will be collected when the participant returns to the hospital or alternatively be collected at a medical clinic convenient to the participant. Another telephone interview will occur at 12 months. Participants' blood samples will be stored for future biologic and genetic studies.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2985
- Elevated cardiac markers within 24 hours of arrival at initial or enrolling institution
- Supporting evidence suggestive of a heart attack
- Previously enrolled in the VIRGO study
- Does not speak English or Spanish
- Too ill to interview
- Current prisoner
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (92)
Saddleback Memorial Medical Center
🇺🇸Laguna Hills, California, United States
Providence Hospital
🇺🇸Mobile, Alabama, United States
Sharp Gross Hospital
🇺🇸La Mesa, California, United States
Long Beach Memorial Medical Center
🇺🇸Long Beach, California, United States
University of Southern California
🇺🇸Los Angeles, California, United States
Cedars-Sinai Medical Center/PRCC Cardiology Research
🇺🇸Los Angeles, California, United States
Stanford University Medical Center
🇺🇸Stanford, California, United States
Memorial Medical Center (Sutter Gould Medical Foundation)
🇺🇸Modesto, California, United States
St Elizabeth's Hospital
🇺🇸Belleville, Illinois, United States
Denver Health Medical Center
🇺🇸Denver, Colorado, United States
St Joseph's Medical Center
🇺🇸Stockton, California, United States
Torrance Memorial Medical Center
🇺🇸Torrance, California, United States
Los Robles Hospital and Medical Center
🇺🇸Thousand Oaks, California, United States
Bridgeport Hospital
🇺🇸Bridgeport, Connecticut, United States
St Francis Hospital and Medical Center
🇺🇸Hartford, Connecticut, United States
Citrus Memorial Health Systems
🇺🇸Inverness, Florida, United States
University of Chicago Medical Center
🇺🇸Chicago, Illinois, United States
Northshore University Health System
🇺🇸Evanston, Illinois, United States
Memorial Health System
🇺🇸Springfield, Illinois, United States
Parkview Hospital
🇺🇸Fort Wayne, Indiana, United States
University of Iowa Hospitals and Clinics
🇺🇸Iowa City, Iowa, United States
Genesis Medical Center
🇺🇸Davenport, Iowa, United States
Cotton-O'Neil Clinical Research Center
🇺🇸Topeka, Kansas, United States
Cardiovascular Research Foundation of Louisiana
🇺🇸Baton Rouge, Louisiana, United States
Central Maine Heart and Vascular Institute
🇺🇸Lewiston, Maine, United States
Sparrow Hospital
🇺🇸Lansing, Michigan, United States
Spectrum Health
🇺🇸Grand Rapids, Michigan, United States
Oakwood Hospital and Medical Center
🇺🇸Dearborn, Michigan, United States
Mount Clemens Regional Medical Center
🇺🇸Mount Clemens, Michigan, United States
Munson Medical Center
🇺🇸Traverse City, Michigan, United States
Cox South Hospital
🇺🇸Springfield, Missouri, United States
St John's Regional Medical Center
🇺🇸Joplin, Missouri, United States
Heartland Cardiovascular Consultants
🇺🇸Saint Joseph, Missouri, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
St John's Medical Research Institute
🇺🇸Springfield, Missouri, United States
Bozeman Deaconess Hospital
🇺🇸Bozeman, Montana, United States
Glacier View Cardiology
🇺🇸Kalispell, Montana, United States
BryanLGH Heart Institute
🇺🇸Lincoln, Nebraska, United States
Good Samaritan Hospital
🇺🇸Kearney, Nebraska, United States
St Rita's Medical Center
🇺🇸Lima, Ohio, United States
Heart Institute of the Cascades
🇺🇸Bend, Oregon, United States
Samaritan Heart & Vascular Institute
🇺🇸Corvallis, Oregon, United States
The International Heart Institute of Montana
🇺🇸Missoula, Montana, United States
Erie County Medical Center
🇺🇸Buffalo, New York, United States
The Valley Hospital
🇺🇸Ridgewood, New Jersey, United States
Presbyterian Heart Group
🇺🇸Albuquerque, New Mexico, United States
Overlook Hospital
🇺🇸Summit, New Jersey, United States
Stony Brook University Medical Center
🇺🇸Stony Brook, New York, United States
Presbyterian Hospital - Mid Carolina Cardiology
🇺🇸Charlotte, North Carolina, United States
Presbysterian Hospital - Mid Carolina Cardiology
🇺🇸Charlotte, North Carolina, United States
Winthrop University Hospital
🇺🇸Mineola, New York, United States
Summa Health System (Akron City Hospital)
🇺🇸Akron, Ohio, United States
Geisinger Clinic - Cardiology
🇺🇸Danville, Pennsylvania, United States
Pinnacle Health System
🇺🇸Harrisburg, Pennsylvania, United States
Hamot Medical Center
🇺🇸Erie, Pennsylvania, United States
D. Guthrie Foundation for Education & Research
🇺🇸Sayre, Pennsylvania, United States
Baylor Research Institute
🇺🇸Dallas, Texas, United States
Fletcher Allen Health Care
🇺🇸Burlington, Vermont, United States
Sharon Regional Health System
🇺🇸Sharon, Pennsylvania, United States
University of Texas Southwestern Medical Center at Dallas (UTSW)
🇺🇸Dallas, Texas, United States
Sentara Hospital
🇺🇸Norfolk, Virginia, United States
Waukesha Memorial Hospital
🇺🇸Waukesha, Wisconsin, United States
St Mary's Medical Center
🇺🇸Huntington, West Virginia, United States
Mercy Hospital and Medical Center
🇺🇸Chicago, Illinois, United States
The Ohio State University Medical Center
🇺🇸Columbus, Ohio, United States
Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Boston Medical Center
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
The Indiana Heart Hospital
🇺🇸Indianapolis, Indiana, United States
St Vincent Hospital & Health Services
🇺🇸Indianapolis, Indiana, United States
Baptist Cardiac & Vascular Institute, Baptist Hospital of Miami
🇺🇸Miami, Florida, United States
Krannert Heart Institute - Indiana University - Clarian Methodist Hospital
🇺🇸Indianapolis, Indiana, United States
Minneapolis Heart Institute
🇺🇸Minneapolis, Minnesota, United States
California Medical Center
🇺🇸San Francisco, California, United States
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
St John Hospital & Medical Center
🇺🇸Detroit, Michigan, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
Centura Research Center
🇺🇸Denver, Colorado, United States
Pepin Heart Research Institute
🇺🇸Tampa, Florida, United States
Sutter Medical Center Sacramento
🇺🇸Sacramento, California, United States
Mercy General Hospital
🇺🇸Sacramento, California, United States
Yale University School of Medicine
🇺🇸New Haven, Connecticut, United States
Hospital of St. Raphael
🇺🇸New Haven, Connecticut, United States
Orlando Health
🇺🇸Orlando, Florida, United States
Mid-America Heart Institute, St Luke's Hospital
🇺🇸Kansas City, Missouri, United States
University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Forsyth Medical Center
🇺🇸Winston-Salem, North Carolina, United States
Butler Memorial Hospital
🇺🇸Butler, Pennsylvania, United States
Virginia Commonwealth University
🇺🇸Richmond, Virginia, United States
Montefiore/Albert Einstein Medical Center
🇺🇸Bronx, New York, United States
Jacobi Medical Center
🇺🇸Bronx, New York, United States
Rhode Island Hospital
🇺🇸Providence, Rhode Island, United States