A nUtrition and Lifestyle Intervention in Patients With Pulmonary Arterial HypertensIon: Effect on quaLity of Life
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change in quality of life
研究概览
简要总结
Rationale: Nutrition and lifestyle interventions are currently not implemented in usual clinical care of PAH-patients. Mainly because there is little known on the relation between pathology, nutrition and lifestyle. Patients who suffer from Pulmonary Arterial Hypertension feel insecure about their nutrition and lifestyle. The investigators hypothesize that an intervention on nutrition and lifestyle can improve the patients' quality of life.
Objective: To explore the effect of a nutrition and lifestyle intervention on quality of life for patients suffering from PAH.
Study design: Investigator initiated intervention study with control group. Study population: investigators aim to include 70 patients (18 - 80 years) with idiopathic, hereditable or drug related PAH, who have been stable for at least three months and are self-sufficient and/or have a family who's willing to participate in the lifestyle changes.
Intervention (if applicable): Nutritional status, - education, - intervention and - compliance.
Main study parameters/endpoints: This is an intervention study in which the investigators will asses the effect of a nutrition and lifestyle intervention on quality of life measured by SF-36 overall outcome with a significant difference of 6.35.
Nature and extent of the burden and risks associated with participation, benefit and group relatedness: The burden for the patient exists of 12 extra visits to the hospital and contact moments, over a period of 11 months, as well compliance to the diet and lifestyle. There is minimal risk in participation.
详细描述
Baseline nutritional assessment
Nutritional education:
8 online lessons containing information about nutrition, lifestyle and general health with complementary tips regarding PH. All participants recieve workbook with assignments.
Nutritional intervention:
Group A: MedDASH diet (55% carbohydrates, 25% amino acids, 20% fatty acids) Group B: MedDASHfat diet (10% carbohydrates, 25% amino acids, 65% fatty acids) Control group: no diet.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- Single (Participant)
盲法说明
Randomisation control and E-learning Randomisation Diet A and B
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of idiopathic PAH, hereditable PAH or drug related PAH
- •Age between 18 and 80
- •NYHA II or III and stable for at least 3 months, determined by a stable 6minute walk test with a difference of <10%.
- •Self-sufficient and/or compliance from partner and/or family
- •Creatinine > 30 ml/min
- •Able to understand and willing to sign the Informed Consent Form
排除标准
- •- Pregnant subjects
- •Fat percentage < 10% > 50 %
- •One or more of the following comorbidities: diabetes mellitus type one or two, clinically relevant thyroid disease
- •Known history of noncompliance considering therapies
研究组 & 干预措施
Control
No intervention
E-learning
E-learning: 8 lessons about nutrition and lifestyle
干预措施: E-learning (Behavioral)
Diet A
MedDASH diet (55% carbohydrates, 25% amino acids, 20% fatty acids)
干预措施: E-learning (Behavioral)
Diet A
MedDASH diet (55% carbohydrates, 25% amino acids, 20% fatty acids)
干预措施: Diet (Dietary Supplement)
Diet B
MedDASHfat diet (10% carbohydrates, 25% amino acids, 65% fatty acids)
干预措施: E-learning (Behavioral)
Diet B
MedDASHfat diet (10% carbohydrates, 25% amino acids, 65% fatty acids)
干预措施: Diet (Dietary Supplement)
结局指标
主要结局
Change in quality of life
时间窗: Baseline (week 0), after nutritional education (week 10), after nutritional intervention (week 24), after follow up (week 48)
To asses quality of life, the SF-36 questionnaire is used.
次要结局
- Change in nutritional intake(Baseline (week 0), after nutritional education (week 10), after nutritional intervention (week 24), after follow up (week 48))
- Change in vitamin and mineral status(Baseline (week 0), after nutritional education (week 10), after nutritional intervention (week 24), after follow up (week 48))
研究者
A. Vonk Noordegraaf
Prof. Dr.
Amsterdam UMC, location VUmc