PLATELET RICH FIBRIN COMBINED WITH 1.2% ATORVASTATIN FOR TREATMENT OF INTRABONY DEFECTS IN CHRONIC PERIODONTITIS
- Conditions
- Periodontitis
- Interventions
- Registration Number
- NCT02119520
- Lead Sponsor
- Government Dental College and Research Institute, Bangalore
- Brief Summary
Current study was designed to evaluate the combined efficacy of PRF and 1.2% ATV gel with open flap debridement (OFD) in treatment of intrabony defects in chronic periodontitis subjects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 96
the presence of 3- wall IBD ≥3 mm deep (distance between alveolar crest and base of the defect on an intraoral periapical radiograph [IOPA]) along with an interproximal probing depth (PD) ≥5 mm after phase I therapy (scaling and root planing [SRP]) in asymptomatic teeth.
- Agressive Periodontitis subjects; 2) Systemic conditions known to affect the periodontal status; 3) medications known to affect the outcomes of periodontal therapy; 4) Hematological disorders and insufficient platelet count (<200,000/mm3); 5) pregnancy/lactation; and 6) Smoking and tobacco use in any form 7) Immunocompromised individuals.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Platelet rich fibrin + atorvastatin Platelet rich fibrin +Atorvastatin In Platelet rich fibrin+ATV group PRF combined with 10 µl of 1.2% ATV was inserted into the depth of the IBD Platelet rich fibrin Platelet rich fibrin In Platelet rich fibrin group PRF was inserted into the depth of the IBD. Open flap debridement open flap debridement open flap debridement was followed by no grafting or regenerative intervention.
- Primary Outcome Measures
Name Time Method Percentage radiographic defect depth reduction 9 months from baseline Defect depth reduction will be assessed from baseline to 9 month post operatively on radiographs
- Secondary Outcome Measures
Name Time Method change in probing depth 9 months from baseline probing depth will be assessed from gingival margin to pocket depth at baseline and 9 months postoperatively
change in relative attachment level 9 months from baseline RAL will be assesed from fixed point on the stent at baseline and 9 months postoperatively
change in plaque levels 9 months from baseline plaque levels were assessed at baseline and 9 months postoperatively
change in gingival bleeding 9 months from baseline gingival bleeding was assesed at baseline and 9 months postoperatively
change in gingival margin levels 9 months from baseline change in gingival margin levels were assesed at baseline and 9 months
Trial Locations
- Locations (1)
Govt dental college and research institute
🇮🇳Bangalore, Karnataka, India