Association Between Asthma and Food Allergy

Not Applicable

• Conditions: Food Allergy Proved; Food Allergy Suspected
• Interventions: Other: Pulmonary function test

• Registration Number: NCT02884583
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

Prevalences of food allergies and asthma increased in the population during the last decades. These two pathologies, responsible for a real burden, are often associated and are to be considered as comorbidities; this aspect is more and more studied in the literature and many authors tried to find a link between diets and asthma. The narrow link between these two atopic pathologies and the fact that food allergy can come along with respiratory symptoms also in patients without history of asthma must be better understood, considered into the management of food allergy. The main objective of this study is to study the prevalence of signs and/or symptoms suggestive of bronchial hyperreactivity, during an oral food challenge (OFC) in patients older than 5 years. The secondary objective is to study the risk factors to develop asthma during a food allergy reaction.

This historical-prospective single center study , was realized in the Allergy Unit of the University Hospital of Montpellier. All the patients having been hospitalized for a positive OFC between January, 2001 and January, 2016 were included. The diagnosis of asthma was established according to the recommended international clinical and physiological criteria. Prevalence of bronchial hyperreactivity during OFC among those with positive OFC, was calculated. The search for risk factors was made by a logistic regression univariate then multivariate, completed by a decision tree.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-04-26
• Study First Submitted: 2016-07-18
• Status Verified: 2016-08
• Study First Submitted QC: 2016-08-25
• Study First Posted: 2016-08-31
• Last Update Submitted: 2017-11-02
• Last Update Posted: 2017-11-06
• Primary Completion: 2018-03
• Study Completion: 2018-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patient hospitalized for oral food challenge at the hospital

Exclusion Criteria

• Patient want to leave the protocol
• Patient take medication forbidden during the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Pulmonary function test	Pulmonary function test	Patients hospitalized for Oral Food Challenge realize pulmonary function test

Primary Outcome Measures

Name	Time	Method
Number of patient with bronchospasm in OFC	up to 3 hours

Secondary Outcome Measures

Name	Time	Method
Questionnaire for the assessment of the responsible food of allergy	up to 3 hours
the eliciting dose	up to 3 hours	the dose of the tested food which elicits the symptoms of allergy
The grade of the allergic reaction shown during the last food ingestion of the concerned food	up to 3 hours
The presence of one or several sensitisations associated with respiratory allergens	up to 3 hours	defining the atopic ground
The level of specific immunoglobulin E of the concerned food	up to 3 hours
The time of appearance of the first signs of atopy	up to 3 hours
questionnaire for the assessment of the mode of clinical expression of food allergies	up to 3 hours

Trial Locations

Locations (1)

University hospital of Montpellier; 🇫🇷 Montpellier, France