se of Cardiac MRI in patients with presumed heart attack and unobstructed coronary arteries

Not Applicable

• Conditions: Clinical decision-making in myocardial infarction with non-obstructive coronary arteries; Circulatory System

• Registration Number: ISRCTN75233845
• Lead Sponsor: South Tees Hospitals NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-02-23
• Last Update Posted: 4 July 2023
• Study Completion: 2024-01-06

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

1. Presentation with MINOCA (as per the 2016 ESC consensus statement definition)
2. Presence of diagnostic uncertainty* as to the underlying mechanism.
3. Treating clinician intends to further assess by CMR
4. Age >18 years
*Diagnostic uncertainty is defined as at least some doubt on the part of the treating clinician as to the underlying mechanism for the MINOCA, and quantified as a certainty level =8 (range 1-10, with 1 being fully uncertain and 10 being fully certain)

Exclusion Criteria

1. Treating cardiologist deems the diagnosis is already felt to be secure (=9 of the certainty scale which has a range 1-10)
2. CMR is contra-indicated or not planned
3. Type II myocardial infarction rather than MINOCA
4. Symptom onset >2 weeks prior to CMR
5. Pregnancy
6. Does not have capacity to consent

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnosis and management assessment completed by the treating cardiologist before and after the patient has undergone the cardiac MRI (questionnaire assessment of working diagnosis, diagnostic certainty [scale 1 - 10] and clinical management)

Secondary Outcome Measures

Name	Time	Method
<br> Assessment completed by the treating cardiologist before and after the patient has undergone the cardiac MRI (questionnaire assessment of working diagnosis, diagnostic certainty [scale 1 - 10], and clinical management):<br> 1. Diagnosis<br> 2. Diagnostic certainty<br> 3. Management<br> 4. Incidence of recurrent myocardial infarction at 1 year measured using patient records<br> 5. Incidence of clinically-significant bleeding (Bleeding Academic Research Consortium (BARC) Type II, III or V) at 1 year measured using patient records<br>