The Clinical Utility of Capsaicin Dose Response Curves to Discriminate Cough Hyper-responsiveness

niversity Hospital of South Manchester NHS Foundation Trust (UK)0 个研究点目标入组 200 人开始时间: 2014年1月23日最近更新: 2023年2月20日

适应症

试验速览

•Healthy volunteers:
•1. Male and female aged over 18 years
•2. Normal spirometry
•3. No current or past history of chronic cough or respiratory disease
•4. No current chronic pain, irritable bowel syndrome, psychiatric illness or chronic headaches
•Chronic cough patients:
•1. Male and female aged over 18 years
•2. Diagnosis of chronic cough (defined as cough lasting more than 8 weeks)
•3. Normal spirometry
•4. Normal chest x-ray

•1. Current smoker or ex-smoker with >20 pack year history, and >6 months abstinence
•2. Upper respiratory tract infection within last 4 weeks
•3. Use of angiotensin-converting-enzyme (ACE) inhibitors
•4. Use of any centrally acting medications which may alter the cough reflex*
•5. History of drug or alcohol abuse
•6. Pregnancy or breastfeeding
•7. Concomitant conditions which may alter cough reflex sensitivity e.g. diabetes mellitus, Parkinson?s disease, cerebrovascular disease.

发起方

niversity Hospital of South Manchester NHS Foundation Trust (UK)