ISRCTN23684347
Completed
未知
The Clinical Utility of Capsaicin Dose Response Curves to Discriminate Cough Hyper-responsiveness
niversity Hospital of South Manchester NHS Foundation Trust (UK)0 sites200 target enrollmentJanuary 23, 2014
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Chronic cough
- Sponsor
- niversity Hospital of South Manchester NHS Foundation Trust (UK)
- Enrollment
- 200
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
2017 Results article in https://www.ncbi.nlm.nih.gov/pubmed/27444176 results 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/36736541/ (added 06/02/2023)
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy volunteers:
- •1\. Male and female aged over 18 years
- •2\. Normal spirometry
- •3\. No current or past history of chronic cough or respiratory disease
- •4\. No current chronic pain, irritable bowel syndrome, psychiatric illness or chronic headaches
- •Chronic cough patients:
- •1\. Male and female aged over 18 years
- •2\. Diagnosis of chronic cough (defined as cough lasting more than 8 weeks)
- •3\. Normal spirometry
- •4\. Normal chest x\-ray
Exclusion Criteria
- •1\. Current smoker or ex\-smoker with \>20 pack year history, and \>6 months abstinence
- •2\. Upper respiratory tract infection within last 4 weeks
- •3\. Use of angiotensin\-converting\-enzyme (ACE) inhibitors
- •4\. Use of any centrally acting medications which may alter the cough reflex\*
- •5\. History of drug or alcohol abuse
- •6\. Pregnancy or breastfeeding
- •7\. Concomitant conditions which may alter cough reflex sensitivity e.g. diabetes mellitus, Parkinson?s disease, cerebrovascular disease.
Outcomes
Primary Outcomes
Not specified
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