A Short-term Mixed Exercise for Sarcopenic Hospitalized Aged 80+ Years

Not Applicable

Completed

• Conditions: Sarcopenia
• Interventions: Behavioral: balance training; Behavioral: usual care; Behavioral: resistance training; Behavioral: aerobic exercise

• Registration Number: NCT04355299
• Lead Sponsor: Yuxiang Liang

Brief Summary

Most previous clinical trials that addressed exercise for sarcopenic elderly subjects focused on community-dwelling older adults who were relatively healthy. There is a notable paucity of high-quality research investigating the effects and feasibility of exercise for hospitalized or institutionalized older people, who are generally frailer and more severe in functional impairment than those living in the community. Moreover, most reported exercise programs were of long-term duration, which typically lasted 3 to 6 months with two sessions per week. It remains unclear whether short-term exercise would be effective for treating sarcopenia. Therefore, the investigators aimed to assess the effectiveness of short-term exercise for treating sarcopenia in hospitalized older patients aged 80 years and over.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-10-01
• Primary Completion: 2019-12-30
• Study Completion: 2020-01-01
• Status Verified: 2020-04
• Study First Submitted: 2020-04-17
• Study First Submitted QC: 2020-04-20
• Last Update Submitted: 2020-04-20
• Study First Posted: 2020-04-21
• Last Update Posted: 2020-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 121

Inclusion Criteria

1. aged ≥80 years;
2. being able to ambulate (assistance was acceptable);
3. being able to communicate and collaborate with the physiotherapist;
4. with sarcopenia defined by the AWGS criteria ;

Exclusion Criteria

1. terminal illness;
2. uncontrolled heart failure;
3. myocardial infarction within the past three months;
4. uncontrolled respiratory failure;
5. bone fractures within the past three months;
6. acute pulmonary embolism;
7. major surgery within the past three months;
8. uncontrolled arrhythmia;
9. refusal to participate in this study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention group	balance training	a mixed exercise program including aerobic, balance, and resistance exercises that were personally tailored.
Intervention group	resistance training	a mixed exercise program including aerobic, balance, and resistance exercises that were personally tailored.
Intervention group	aerobic exercise	a mixed exercise program including aerobic, balance, and resistance exercises that were personally tailored.
control group	usual care	usual care

Primary Outcome Measures

Name	Time	Method
The change of activities of daily living from the baseline to the end of the 2-week intervention	2 weeks	Basic activities of daily living (BADL) assessed by Barthel Index. The total score for Barthel Index ranges from 0 (worst) to 100 (best) points.

Secondary Outcome Measures

Name	Time	Method
The change of handgrip strength	2 weeks	Handgrip strength was measured using a digital grip dynamometer
The change of gait speed	2 weeks	Gait speed was measured using a 4-meter walking test.
The change of the score of Short Physical Performance Battery	2 weeks	The Short Physical Performance Battery (SPPB) is an objective assessment tool for evaluating lower extremity functioning in older persons. The total score for SPPB ranges from 0 (worst) to 12 (best) points.
The change of the score of Timed Up and Go test	2 weeks	The Timed Up and Go test (TUG) is a simple test used to measure basic functional mobility and safety with mobility. The score for the TUG is the time consumption of the whole process. The longer time consuption indicates the more worse outcome.