Comparative, non-randomized study for keratosis pilaris (A condition that causes rough patches and small, acne-like bumps on the skin)

Completed

• Conditions: Follicular disorder, unspecified, (2) ICD-10 Condition: 8||Other Procedures,

• Registration Number: CTRI/2022/12/048073
• Lead Sponsor: NA

Brief Summary

•     Keratosis pilaris is a common follicularkeratinization disorder.

•     Characterized by follicular papules andperifollicular erythema.

•     It typically presents as symmetric,asymptomatic eruption predominantly on the extensor aspects of the proximalparts of the limbs but may involve the face, buttocks and trunk.

•     Often, the condition is inherited in anautosomal dominant manner.

•     Thesmall papules impart a stippled appearance to the skin, resembling gooseflesh.

•     Itsincidence is approximately 50% in adolescents and many patients undergoremission in adulthood.

•     Thiscondition can be cosmetically very disturbing, especially in the teenagers orfemale patients.

•     There is no absolute cure for keratosispilaris, but various treatment modalities reduce symptoms.

•     Emollients, keratolytic agents, topicalretinoids can be used for treatment, but their efficacy is limited.

•     Recently, the effectiveness of lasertreatments such as fractional CO2 laser, 810nm Diode laser, Q-switched Nd:YAGlaser has been demonstrated.

•     In this study, we intend to compare the efficacy of Erb:YAG and FRAC3  Nd:YAG laser and combination of both, withregard to improvement in dyspigmentation and skin roughness in KeratosisPilaris.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-12-14
• Study Completion: 2022-12-20
• Last Update Posted: 2024-02-24

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Age >18 years presenting with KP lesions.

Exclusion Criteria

• •Patients on topical treatment (steroids, keratolytics, retinoids) 1 month before the laser treatment •Patients who received laser for the treatment of keratosis Pilaris in the last 6 months.
• •History of autoimmune disease •History of Keloid & hypertrophic scar.
• •Pregnant or lactating women.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the effectiveness of Fractional Erbium: YAG laser, FRAC3 Nd: YAG laser and combination of both in the improvement of skin roughness, reduction of pigmentation and redness.	Baseline(week 0), week 4, week8, week 12 and week 16

Secondary Outcome Measures

Name	Time	Method
To assess the patient satisfaction regarding the treatment response with respect to Fractional Erbium : YAG , FRAC3 Nd: YAG and combination of both lasers.	baseline(week 0) and week 16

Trial Locations

Locations (1)

CUTIS Academy of Cutaneous Sciences; 🇮🇳 Bangalore, KARNATAKA, India

CUTIS Academy of Cutaneous Sciences

🇮🇳Bangalore, KARNATAKA, India

Dr Sunaina

Principal investigator

9573828707

sunainasheikh18@gmail.com