Effects of edaravone on early postoperative cognitive function in elderly patients undergoing hip joint replacement surgery
Phase 1
Recruiting
- Conditions
- Postoperative cognitive dysfunction
- Registration Number
- ITMCTR1900002523
- Lead Sponsor
- Shanghai Pudong Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Patients aged 60 years and over; received hip joint replacement surgery; informed consent; ASA I or II.
Exclusion Criteria
History of psychiatric disorders, cerebrovascular diseases and diabetes; long term use of nervous and mental system drugs (such as sedative hypnotics and antidepressants); history of alcohol abuse; severe impairment on speaking, hearing and vision that difficult to communicate; MMSE score < 23 one day before surgery.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Simple Mental State Scale Score;the level of SOD in plasma;the level of MDA in plasma;
- Secondary Outcome Measures
Name Time Method the level of S100ß in plasma;the level of IL-6 in plasma;the level of MMP-9 in plasma;