Impact of Hepatectomy on HCC Recurrence

Completed

• Conditions: Recurrence; Hepatocellular Carcinoma Stage I
• Interventions: Procedure: Major hepatectomy

• Registration Number: NCT06390228
• Lead Sponsor: Anhui Medical University

Brief Summary

Hepatectomy is the first option for the treatment of hepatocellular carcinoma(HCC) at CNLC Ib stage. HCC patients who undergo curative hepatectomy may experience varying remnant liver volumes and thus leads to different oncological outcomes.

Detailed Description

Patients with hepatocellular carcinoma (HCC) who undergo curative hepatectomy may experience varying remnant liver volumes. The investigators aimed to evaluate whether the extent of liver resection has an effect on postoperative recurrence in HCC patients. A retrospective analysis was conducted on 197 patients who underwent hepatectomy for a solitary HCC lesion measuring ≥5 cm between January 2019 and June 2022. Patients were divided into major hepatectomy (MAH) group (n=70) and minor hepatectomy (MIH) group (n=127) based on the extent of liver resection. Recurrence-free survival (RFS) was compared between the two groups. Propensity score matching was employed to mitigate potential biases in this research.

Study Timeline

• Study Start: 2019-01-01
• Primary Completion: 2023-08-01
• Study Completion: 2023-08-01
• Status Verified: 2024-04
• Study First Submitted: 2024-04-24
• Study First Submitted QC: 2024-04-26
• Last Update Submitted: 2024-04-26
• Study First Posted: 2024-04-30
• Last Update Posted: 2024-04-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 197

Inclusion Criteria

• histologically confirmed solitary HCC with a size of ≥5 cm
• Eastern Cooperative Oncology Group score of 0 or 1
• preoperative indocyanine green retention rate at 15 minutes ≤15% and Child-Pugh A classification
• no evidence of vascular invasion or extrahepatic disease.

Exclusion Criteria

• not diagnosed with HCC or had an HCC measuring <5 cm
• had confirmed tumor metastases or macrovascular invasion based on radiological examinations
• died within 90 days after surgery were excluded

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Major hepatectomy	Major hepatectomy	Major hepatectomy was defined as the removal of four or more Couinaud's liver segments.

Primary Outcome Measures

Name	Time	Method
recurrence-free survival	2019.1-2023.8	the time from the time of radical surgery to the time of HCC recurrence

Trial Locations

Locations (1)

Anhui Provincial Hospital; 🇨🇳 Hefei, Anhui, China