Impact of Major Hepatectomy on Recurrence After Resection of Hepatocellular Carcinoma at China Liver Cancer Staging (CNLC) Stage : a Propensity Score Matching Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 197
- 试验地点
- 1
- 主要终点
- recurrence-free survival
研究概览
简要总结
Hepatectomy is the first option for the treatment of hepatocellular carcinoma(HCC) at CNLC Ib stage. HCC patients who undergo curative hepatectomy may experience varying remnant liver volumes and thus leads to different oncological outcomes.
详细描述
Patients with hepatocellular carcinoma (HCC) who undergo curative hepatectomy may experience varying remnant liver volumes. The investigators aimed to evaluate whether the extent of liver resection has an effect on postoperative recurrence in HCC patients. A retrospective analysis was conducted on 197 patients who underwent hepatectomy for a solitary HCC lesion measuring ≥5 cm between January 2019 and June 2022. Patients were divided into major hepatectomy (MAH) group (n=70) and minor hepatectomy (MIH) group (n=127) based on the extent of liver resection. Recurrence-free survival (RFS) was compared between the two groups. Propensity score matching was employed to mitigate potential biases in this research.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •histologically confirmed solitary HCC with a size of ≥5 cm
- •Eastern Cooperative Oncology Group score of 0 or 1
- •preoperative indocyanine green retention rate at 15 minutes ≤15% and Child-Pugh A classification
- •no evidence of vascular invasion or extrahepatic disease.
排除标准
- •not diagnosed with HCC or had an HCC measuring <5 cm
- •had confirmed tumor metastases or macrovascular invasion based on radiological examinations
- •died within 90 days after surgery were excluded
结局指标
主要结局
recurrence-free survival
时间窗: 2019.1-2023.8
the time from the time of radical surgery to the time of HCC recurrence
次要结局
未报告次要终点
研究者
Kunyuan Jiang
Clinical Professor
Anhui Medical University