NCT04731584已完成不适用
Systemic Inflammation During Recanalization of Cerebral Arterial Occlusion
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 4
- 主要终点
- Inflammation parameters description
研究概览
简要总结
Strokes management, secondary to proximal arterial occlusion, by endovascular thrombectomy (TM) is now well established. The immuno-inflammatory events of reperfusion after TM are discussed. Systemic inflammation is a major factor suggested to explain the limited recovery of the ischemic parenchyma. Understanding these phenomena is necessary before developing an immunomodulatory strategy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults patient (s)
- •Ischemic stroke by occlusion of a middle cerebral artery (proximal portion M1)
- •Initial diagnostic MRI infusion
- •TM with complete reperfusion (TICI 2b, 2c or 3)
- •TM performed under local anesthesia +/- anxiolysis, or sedation including propofol
- •mRS prior to stroke <2
- •Barthel index <90
- •Included in the HIBISCUS cohort
- •Patient who was informed and did not object to participating in the study OR included through the emergency procedure then collection of his non-objection or that of his trusted person as soon as possible
排除标准
- •NIHSS awareness score> or = 2
- •Haemorrhagic complication before thrombectomy
- •Pregnant woman
- •Multiple vascular occlusions
- •Occlusions of posterior or anterior cerebral territories other than M1
- •Protected major
- •TM performed under general anesthesia
- •Other vital failure than neurological failure
- •GROUP "CONTROL" :
- •Inclusion Criteria:
- •Adults patient (s)
- •Barthel index <90
- •Requiring diagnostic arteriography for routine check-up of a cerebrovascular malformation
- •Patient who was informed and did not object to participating in the study
- •Exclusion Criteria:
- •NIHSS awareness score> or = 2
- •Pregnant woman
- •Protected major
- •Exam performed under general anesthesia
结局指标
主要结局
Inflammation parameters description
时间窗: 1 day
Inflammatory parameters such as CRP, IL-6, IL-10, HLA-DR, TNF-alpha, polymorphonuclear chemotaxis, CD-4, T-lymphocytes will be measure in blood sample
次要结局
未报告次要终点
研究者
研究点 (4)
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