Systemic Inflammation During Recanalization of Cerebral Arterial Occlusion

Completed

• Conditions: Stroke; Systemic Infection

• Registration Number: NCT04731584
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Strokes management, secondary to proximal arterial occlusion, by endovascular thrombectomy (TM) is now well established. The immuno-inflammatory events of reperfusion after TM are discussed. Systemic inflammation is a major factor suggested to explain the limited recovery of the ischemic parenchyma. Understanding these phenomena is necessary before developing an immunomodulatory strategy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-01-26
• Study First Submitted QC: 2021-01-26
• Study First Posted: 2021-02-01
• Study Start: 2021-04-07
• Primary Completion: 2021-06-12
• Study Completion: 2021-06-12
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-09
• Last Update Posted: 2023-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Adults patient (s)
• Ischemic stroke by occlusion of a middle cerebral artery (proximal portion M1)
• Initial diagnostic MRI infusion
• TM with complete reperfusion (TICI 2b, 2c or 3)
• TM performed under local anesthesia +/- anxiolysis, or sedation including propofol
• mRS prior to stroke <2
• Barthel index <90
• Included in the HIBISCUS cohort
• Patient who was informed and did not object to participating in the study OR included through the emergency procedure then collection of his non-objection or that of his trusted person as soon as possible

Exclusion Criteria

• NIHSS awareness score> or = 2
• Haemorrhagic complication before thrombectomy
• Pregnant woman
• Multiple vascular occlusions
• Occlusions of posterior or anterior cerebral territories other than M1
• Protected major
• TM performed under general anesthesia
• Other vital failure than neurological failure

GROUP "CONTROL" :

Inclusion Criteria:

• Adults patient (s)
• mRS <2
• Barthel index <90
• Requiring diagnostic arteriography for routine check-up of a cerebrovascular malformation
• Patient who was informed and did not object to participating in the study

Exclusion Criteria:

• NIHSS awareness score> or = 2
• Pregnant woman
• Protected major
• Exam performed under general anesthesia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Inflammation parameters description	1 day	Inflammatory parameters such as CRP, IL-6, IL-10, HLA-DR, TNF-alpha, polymorphonuclear chemotaxis, CD-4, T-lymphocytes will be measure in blood sample

Trial Locations

Locations (4)

Service d'Anesthésie Réanimation Hôpital - Neurologique/Groupement Est; 🇫🇷 Bron, France

Service de Neurologie vasculaire - Hôpital Neurologique/Groupement Est; 🇫🇷 Bron, France

Service de Neuroradiologie interventionnelle - Hôpital Neurologique/Groupement Est; 🇫🇷 Bron, France

Service d'Anesthésie Réanimation - Hôpital Edouard Herriot/Groupement Centre; 🇫🇷 Lyon, France