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Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

Phase 2
Recruiting
Conditions
Heart Failure
Interventions
Other: Placebo
Registration Number
NCT06122779
Lead Sponsor
Bristol-Myers Squibb
Brief Summary

The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HFpEF).

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
208
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
SEQUENTIAL
Arm && Interventions
GroupInterventionDescription
PlaceboPlacebo-
BMS-986435BMS-986435-
Primary Outcome Measures
NameTimeMethod
Incidence of treatment emergent adverse events (TEAEs)Up to approximately 24 weeks
Incidence of serious adverse events (SAEs)Up to approximately 24 weeks
Incidence of AEs leading to treatment discontinuationUp to approximately 20 weeks
Secondary Outcome Measures
NameTimeMethod
Summary of plasma concentrations of MYK-224Up to approximately 20 weeks

Trial Locations

Locations (116)

Peking Union Medical College Hospital - East Campus

🇨🇳

Beijing, Beijing, China

Local Institution - 0116

🇮🇱

Safed, Israel

University of Alabama at Birmingham

🇺🇸

Birmingham, Alabama, United States

Local Institution - 0096

🇺🇸

Lakewood, Colorado, United States

Local Institution - 0077

🇺🇸

Jacksonville, Florida, United States

Infinite Clinical Research

🇺🇸

Miami, Florida, United States

Local Institution - 0099

🇺🇸

Miami, Florida, United States

Local Institution - 0014

🇺🇸

Atlanta, Georgia, United States

Local Institution - 0048

🇺🇸

Atlanta, Georgia, United States

Bluhm Cardiovascular Institute of Northwestern

🇺🇸

Chicago, Illinois, United States

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Peking Union Medical College Hospital - East Campus
🇨🇳Beijing, Beijing, China
Zhuang Tian, Site 0089
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