ACTRN12612001221842已完成2 期
Randomised Double Blind Placebo Controlled Study to Determine the Effects of Vitamin D supplementation on Platelet and Vascular function in patients with Vitamin D insufficiency and known Coronary artery or peripheral vascular disease
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 40 Years 至 85 Years（—）
- 性别
- All
入选标准
- •Measured Vitamin D level 25-50 nanomol/L
- •Not on Vitamin D replacement therapy for previous 3 months
- •Known history of CAD or PVD
- •Currently taking Aspirin as single anti-platelet therapy
- •Other appropriate arterial disease risk factor reduction therapy
排除标准
- •Age < 40yrs or > 85yrs
- •Measured Vitamin D level < 25nmol/L
- •History of osteoporosis or low-impact fractures
- •Current or planned prenancy
- •Severe renal impairment (eGFR < 30)
- •Current or previous hypercalcemia
- •Known secondary cause of vitamin D insufficiency (eg. malabsorptive states)
- •Presence of an active malignancy
- •Liver cirrhosis
- •Planned coronary artery or peripheral vascular intervention within next 6 months
- •Current oral anticoagulation therapy (eg. Warfarin, Dabigatran)
- •Clopidogrel or anti-epileptic therapy at any stage of the trial periodoAny known hypersensitivity to Vitamin D (cholecalciferol)
研究者
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