Prevalence of Primary Aldosteronism in Atrial Fibrillation

Recruiting

• Conditions: Atrial Fibrillation; Primary Aldosteronism

• Registration Number: NCT05973604
• Lead Sponsor: Aristotle University Of Thessaloniki

Brief Summary

This is an observational prospective cross-sectional study, investigating the prevalence of primary aldosteronism in patients with atrial fibrillation.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-01
• Study First Submitted: 2023-07-19
• Status Verified: 2023-08
• Study First Submitted QC: 2023-08-01
• Last Update Submitted: 2023-08-01
• Study First Posted: 2023-08-03
• Last Update Posted: 2023-08-03
• Primary Completion: 2024-09-01
• Study Completion: 2024-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Established diagnosis of atrial fibrillation with a standard surface ECG tracing of at least 30 seconds (either paroxysmal or persistent or permanent).

Exclusion Criteria

• Diagnosis of primary aldosteronism
• Diagnosis of heart failure, treated with mineralocorticoid receptor antagonists
• Inability to be subjected to any confirmatory tests for primary aldosteronism
• Acute vascular event (acute coronary syndrome, stroke, acute peripheral vascular event) within last 6 months
• Renal replacement therapy
• Incompetence of unwillingness to provide written informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of primary aldosteronism in patients with atrial fibrillation	Baseline	Percentage of patients with positive screening and confirmatory test for primary aldosteronism

Secondary Outcome Measures

Name	Time	Method
Association of echocardiographic indices with presence of primary aldosteronism in patients with atrial fibrillation.	Baseline	Left ventricular global longitudinal strain (GLS) measured by transthoracic echocardiography
Association of marker of arterial stiffness with presence of primary aldosteronism in patients with atrial fibrillation	Baseline	Pulse wave velocity

Trial Locations

Locations (1)

Ippokratio General Hospital; 🇬🇷 Thessaloniki, Greece