The effect of vitamin D deficiency treatment on the improvement of patients with fatty liver disease
- Conditions
- onalcoholic fatty liver disease.Other specified inflammatory liver diseases
- Registration Number
- IRCT2017102218124N5
- Lead Sponsor
- Vice Chancellor for research of Qazvin University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria: Older than 12 years of age; high levels of liver enzymes over the past six months (ALT > 40 U/L); serum vitamin D3 level less than 30 ng/ml; diagnosis to have nonalcoholic fatty liver disease confirmed with sonography results; having non-alcoholic fatty liver disease (NAFLD) and rule out of other hepatic-enzymes rising causes such as viral and autoimmune hepatitis and other chronic liver diseases such as hereditary hemochromatosis, Wilson's disease, an a1- Antitripsin enzyme deficiency; pharmaceutical Hepatitis; consumption of Alcohol.
Pregnancy or lactation; drug abuse; the use of vitamins (multivitamin, vitamin C and vitamin D) in the last 6 months and during the study; weight loss more than 5% during the 6 months before entering the study; diabetes; use of anti-obesity drugs; hypercalcemia; chronic kidney disease; cardio-pulmonary disease; hyperlipidemia which needs medications and Drugs; malignant history; history of the use of effective drugs on the level of ALT such as Valproic acid, Tamoxifen, HMG-COA reductase inhibitors; chemotherapy compounds; Metformin; Statins; Azathioprine; Acetaminophen; antibiotics such as Sulfanamide and Penicillins; Amiodaron; Methotrexate; Isoniazid; Steroids; herbal Medicines; Ursodeoxycholic acid at 3 months before.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hepatic enzymes (aminotransferase). Timepoint: At the beginning of the study and 12 weeks after the intervention. Method of measurement: Measuring the activity of enzymes in serum.
- Secondary Outcome Measures
Name Time Method ipid profiles. Timepoint: At the beginning of the study and 12 weeks after the intervention. Method of measurement: Biochemical method.;Serum level of vitamin D3. Timepoint: At the beginning of the study and 12 weeks after the intervention. Method of measurement: RadioImmuno Assay method.