Perceptual Influences from Smoking Cannabis: an Experimental Study

Not Applicable

Recruiting

• Conditions: Cannabis Use; Stress
• Interventions: Other: Water Temperature Variation - CW; Other: Water Temperature Variation - WW

• Registration Number: NCT06588582
• Lead Sponsor: University of Colorado, Boulder

Brief Summary

The purpose of the study is to better understand the effects of cannabis in relation to mental and physical states including its relationship with mood, cognition, perception including the experience of temperature and pain, and heart rate.

We expect that participants will be in this research study for approximately one week. The total amount of time that participants will spend completing study tasks will be about 2.5 hours across two separate in-person visits.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-09-06
• Study First Submitted QC: 2024-09-06
• Study First Posted: 2024-09-19
• Status Verified: 2024-10
• Study Start: 2025-01-02
• Last Update Submitted: 2025-01-06
• Last Update Posted: 2025-01-07
• Primary Completion: 2029-07-31
• Study Completion: 2029-07-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 166

Inclusion Criteria

• 21-65 years of age
• Endorsement of at least moderate use of cannabis for coping purposes (≥2.5 on CMMQ)
• Regularly use flower cannabis products (i.e., ≥1x/week in the last 6 months)
• Proficient in English language
• At least occasional use of CBD+THC or CBD-dominant products (e.g., ≥1x/month)

Exclusion Criteria

• Diagnosis or use of medications for substance use or psychotic disorders
• Report of other drug use (cocaine, opiates, methamphetamine) in the past 90 days or fail urine screen for any of these drugs
• Females cannot be pregnant or trying to become pregnant or nursing mothers
• Not able to provide informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cold Water	Water Temperature Variation - CW	-
Warm Water	Water Temperature Variation - WW	-

Primary Outcome Measures

Name	Time	Method
Blood Cortisol Levels	Pre-Use/Pre-Water Task, 20 minutes Post-Use, 40 minutes Post-Use	Cortisol levels are measured in blood.
Cannabis Used	Immediate Post-Use	Grams of product used is calculated. Product is measured before and after use to measure how much was used.
Blood Endocannabinoid Levels	Pre-Use/Pre-Water Task, 20 minutes Post-Use	Blood levels of AEA are measured.
Heart Rate	Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use	Participant HR is measured via pulse oximeter.
Social Anxiety	Pre-Use/Pre-Water Task	Social Interaction Anxiety Scale (SIAS). 20 item survey, questions are answered on scale of 0 (not at all) to 4 (extremely), with higher scores indicating higher social anxiety. Questions are summed, with higher overall scores indicating higher social anxiety.
Inhibitory Control	Baseline	Go/No-go Task. Participants are asked to complete a cognitive task where they see the text "Go" or "No go" during different trials. When they see "Go", they need to push a button within 2 seconds. When they see "No-go", they need to make sure they do not press the button (for 2 seconds). This is a measure of impulsivity.
Stress	Pre-Use/Pre-Water Task	Stress Subscale of Depression and Anxiety Stress Scale measures stress. On scale from 0 (does not apply to me at all) to 3 (apply to me very much or most of the time). Higher scores indicate higher stress levels.
Blood cannabinoid levels	Pre-Use/Pre-Water Task, 20 minutes Post-Use	THC and CBD blood levels are measured.
Current Pain	Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use	Internal scale/measure, measured from 0 (no pain) to 10 (worst pain imaginable). Participants report current pain on this self-report scale.
Mood	Pre-Use/Pre-Water Task, Pre-Use/Post-Water Task, 20 minutes Post-Use, 40 minutes Post-Use	Profile of Mood States (POMS). Focus on the stress, anxiety, tension, and relaxation questions (combined for a tension/anxiety subscale). Questions are on a scale 1 (not at all) to 5 (extremely). Scores are summed, with higher scores indicating more tension/anxiety.

Trial Locations

Locations (1)

University of Colorado at Boulder; 🇺🇸 Boulder, Colorado, United States