A randomised controlled trial to evaluate the effects of marked weight loss combined with exercise training on metabolic, immunological, and imaging biomarkers of systemic and brain inflammation in participants undergoing bariatric surgery.

The University of Sydney0 个研究点目标入组 50 人开始时间: 2024年9月3日最近更新: 2024年9月9日

适应症

试验速览

暂无简介。

•18-80 years of age.
•-Eligible for bariatric surgery.
•-Willingness to provide informed consent and willingness to participate and comply with the study requirements

•-Unable to undertake MRI due to size restrictions i.e., shoulder width more than 70 cm.
•-History or clinical manifestation of any other significant metabolic, hematologic, pulmonary, cardio- vascular, gastrointestinal, neurologic, immune, hepatic, renal, urologic, muscular, and joint disorders, or cancer that, in the opinion of the investigator, would make the candidate ineligible for the study. For example, significant joint pain could interfere with adherence to the exercise program.
•-Have objectively assessed cognitive impairment as assessed by the Montreal Cognitive Assessment (MoCA) i.e., total score less than 26.
•-Non-MRI-compatible implanted devices or implants.
•-Inability to exercise via supine ergometer.
•-Claustrophobia.
•-Psychiatric or behavioural problems (history of drug and alcohol abuse, eating disorder).
•-Breastfeeding or pregnant women, or those intending to become pregnant before the scheduled end of the intervention.
•-Unwilling to be assigned at random to the exercise or control intervention.
•-Unwilling or unable to adhere to the rigors of the exercise intervention or evaluation schedule over the entire one-year period.
•-Concurrent participation in any other interventional study.

发起方