Changes in Iron Markers Following Iron Loading in Hemodialysis Patients

Phase 4

Completed

• Conditions: Anemia in Chronic Renal Disease

• Registration Number: NCT00308490
• Lead Sponsor: Papageorgiou General Hospital

Brief Summary

The purpose of this study is to describe alterations of serum ferritin, transferrin saturation, soluble transferrin receptor, % hypochromic erythrocytes, % reticulocytes, reticulocyte hemoglobin content after iron loading in hemodialysis patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-09
• Study First Submitted: 2006-03-28
• Study First Submitted QC: 2006-03-28
• Study First Posted: 2006-03-29
• Status Verified: 2006-09
• Study Completion: 2007-01
• Last Update Submitted: 2007-03-12
• Last Update Posted: 2007-03-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• hemodialysis for three months minimum
• stable epoetin dose for two months minimum
• serum ferritin concentration < 1000 ng/ml
• transferrin saturation < 50%
• parathormone concentration < 800 pg/ml

Exclusion Criteria

• hemoglobin concentration > 13g/dl
• serum ferritin concentration < 20 ng/ml
• vitamin B12 and/or folic deficiency
• other hematologic disease than anemia
• cancer
• hypothyroidism
• infectious disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Ferritin alterations after iron loading at six and twelve weeks from the beginning of iron loading.

Secondary Outcome Measures

Name	Time	Method
All iron indices' alterations during twelve weeks from the beginning of iron loading.

Trial Locations

Locations (1)

Papageorgiou General Hospital; 🇬🇷 Thessaloniki, Greece