Influence of ketamine on the brain.
Recruiting
- Conditions
- Healthy volunteers
- Registration Number
- NL-OMON28020
- Lead Sponsor
- eiden University Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
Healthy right handed male subjects naive to ketamine between 18 to 45 years old.
Exclusion Criteria
1. Obesity (BMI > 30);
2. Significant history of any cardiac or vascular disorder, asthma or other pulmonary disease, major gastrointestinal abnormalities, peptic ulceration, hepatic, neurological, psychiatric, haematological (including bleeding disorders), endocrine, renal, or major genitourinary disease;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Functional MRI;<br /><br>2. Pain scores;<br /><br>3. Ketamine blood concentration.
- Secondary Outcome Measures
Name Time Method 1. Nausea and vomiting;<br /><br>2. Psychomimetic side effects;<br /><br>3. Saliva cortisol measurements.