The Immune System and Psychiatric Disorders

Completed

• Conditions: Stress Disorders, Traumatic; Depressive Disorder; Bipolar Disorder; Personality Disorders; Schizophrenia; Psychotic Disorders

• Registration Number: NCT00184418
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

The study is based on a hypothesis that there is interaction between the activity in the immune system and in the mind. To study this, the investigators register different measures for activity in the immune system on patients unselectedly admitted to an acute psychiatric ward. The psychiatric statuses and diagnoses of these patients are carefully defined as well.

Detailed Description

Our hypotheses are first that activity in the immune system influences the psychiatric status in general, second that changes in activity in psychiatric status affect activity in the immune system and third that there are connections between certain psychiatric conditions/disorders and certain features of the immune system.

All patients admitted to a psychiatric acute ward covering an area with a population of 130.000 and with around 1000 admittances to an acute psychiatric ward a year (some readmittances) are asked to participate in the study. Patients fill in a question form regarding psychiatric as well as somatic health with emphasis on diseases involving immune activity. When possible also slight information on the family is registered. Both at the time of admittance and after recovery clinical laboratory tests on somatic status are registered. In addition the level of different cytokines is measured. The psychiatric state and precise diagnoses are registered during the stay. The data will be analysed to uncover connections between psychiatric stress in general as well as specific psychiatric diagnoses and activity in the immune system.

Study Timeline

• Study Start: 2005-01
• Study First Submitted: 2005-09-15
• Study First Submitted QC: 2005-09-15
• Study First Posted: 2005-09-16
• Primary Completion: 2008-01
• Study Completion: 2008-01
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-09
• Last Update Posted: 2017-03-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1400

Inclusion Criteria

• Admission to the adult acute psychiatric ward of a certain geographical area during the study period

Exclusion Criteria

• Patients that do not agree to participate in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cytokines	1 year

Trial Locations

Locations (1)

St Olavs Hospital, Department of Psychiatry, Østmarka Hospital; 🇳🇴 Trondheim, Middle Norway, Norway