CAtheter versus thoracoscopic Surgical Ablation in long standing persistent atrial fibrillation: a multicentre randomised controlled trial

Royal Brompton & Harefield NHS trust0 个研究点目标入组 120 人开始时间: 2015年4月24日最近更新: 2023年5月29日

适应症

试验速览

2018 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/29458408 protocol 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32860414/ results (added 02/09/2020) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34726873/ (added 19/05/2023)

•Exclusion criteria as of 05/05/2016:
•1. Valvular heart disease with severity greater than mild
•2. Contraindication to anticoagulation
•3. Thrombus in the left atrium despite anticoagulation in therapeutic range
•4. Cerebrovascular accident within the previous 6 months
•5. Previous thoracic or cardiac surgery (including surgical interventions for AF)
•6. Prior left atrial catheter ablation for AF
•7. Unable to provide informed written consent
•8. Active malignancy, another severe concomitant condition or presence of implanted intracardiac devices that would preclude patient undergoing study specific procedures
•9. Pregnant or breast-feeding, or women of childbearing age not using a reliable contraceptive method
•Previous exclusion criteria:
•1. Significant valvular heart disease
•2. Contraindication to anticoagulation
•3. Thrombus in the left atrium despite anticoagulation
•4. Cerebrovascular accident within the previous 6 months
•5. Significant previous thoracic or cardiac surgery (including surgical interventions for AF)
•6. Prior left atrial catheter ablation for AF
•7. Unable to provide informed written consent
•8. Active malignancy or another severe concomitant condition that would preclude patient undergoing study specific procedures
•9. Pregnant or breastfeeding, or women of childbearing age not using a reliable contraceptive method

发起方

Royal Brompton & Harefield NHS trust