Deep Transcranial Magnetic Stimulation as add-on treatment for Children and Adolescents with Obsessive Compulsive Disorder: An open label study

The current study is to be carried out in the National Institute of Mental Health And Neurosciences, Bengaluru. Children and Adolescents with primary diagnosis of OCD and previous failed trial of SSRI/CBT will be recruited for trial of dTMS as an add-on therapy in addition to treatment as usual. It is a single-arm open label trial. Each individual will be screened for inclusion/exclusion criteria, Screening standard questionnaire for TMS safety and comorbidities using DIAMOND-KID. Informed consent from parents and assent from children/adolescents will be taken. 20 sessions of high-frequency deep TMS will be given with one session each day. TMSens_Q, a tool to track adverse effects of TMS will be used to monitor participants and participation will be discontinued in case of any serious adverse effect. OCD severity will be measured using CY-BOCS; Anxiety/depression using RCADS and overall clinical condition using CGI and CGAS scales. Clinical scales will be applied at T1 (Pre-intervention), T2(post-intervention), T3(1 month post-intervention) and T4(3months post-intervention). Linear mixed model will be used to assess the effect of the intervention accounting for within-subject correlations with time as a fixed factor.