Identification of Early Biomarkers of Peritoneal Membrane Dysfunction in Children on Peritoneal Dialysis Using Metabolomics Analysis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Change of Peritoneal Equilibration test profile
研究概览
简要总结
Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis complications and mainly encapsulating peritoneal sclerosis
详细描述
Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis complications and mainly encapsulating peritoneal sclerosis. Identification of peritoneal membrane functional status changes over time, at the same patient (cohort study), by metabolomics, aiming in personalized medicine best practice.
Identification of peritoneal membrane functional status changes over time in immature infants' peritoneal membrane.
Identification of early and accurate markers of peritoneal membrane dysfunction when membrane status is possibly reversible that could predict peritoneal patients at risk for future loss of ultrafiltration and dialysis adequacy of small molecules examined today be PET, KT/V and Cr/Cl (when membrane status is not reversible).
Improve PD survival in infants and children.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Days 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pediatric and adolescent patients on peritoneal dialysis
- •Aged:1month -20 years
排除标准
- •Abdominal surgery
结局指标
主要结局
Change of Peritoneal Equilibration test profile
时间窗: 1 year
Peritoneal Equilibration test
次要结局
- Loss of dialysis adequency(1 year)
- Elevated creatinine(1 year)
研究者
Nikoleta Printza
Associate Prof in Paediatric Nephrology
Aristotle University Of Thessaloniki