跳至主要内容
临床试验/NCT03574298
NCT03574298已完成不适用

Effect of Radical Prostatectomy on Involuntary Pelvic Floor Muscle Contraction

Pierre and Marie Curie University1 个研究点 分布在 1 个国家目标入组 22 人开始时间: 2018年6月18日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
22
试验地点
1
主要终点
Latency (time)

研究概览

简要总结

This study evaluate the effect of radical prostatectomy on involuntary pelvic floor muscle contraction

详细描述

Radical prostatectomy may cause stress urinary incontinence (SUI). That poses problem in terms of quality of life. There are many treatment options available for patients with SUI, but the exact mechanism is not known. We compared, in continent and incontinent men post-radical prostatectomy, the correlation between the temporal course of pelvic floor activation during cough.

Simultaneously, recordings of electromyographic activity of external anal sphincter (EAS EMG) and external intercostal muscle (EIC EMG) during coughing will be made with a pair of pre-gelled electrodes. Cough effort cause an involuntary pelvic contraction. Intercostals muscles recording was chosen because they are one of the muscular components of cough initiation with diaphragm muscle. 24h pad-weighing test is used to quantify urinary incontinence. We will measure the latency between the onset of the EIC EMG and the EAS EMG (RT3), during a cough effort. We will also measure the duration of the contraction, the maximum EAS EMG activity and the area under the curve.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 100 Years(Adult, Older Adult)
性别
Male
接受健康志愿者

入选标准

  • Follow in neuro-urology for lower urinary tract symptoms
  • Radical Prostatectomy

排除标准

  • Perineal Radiotherapy
  • Surgery for stress urinary incontinence

结局指标

主要结局

Latency (time)

时间窗: 1 day: During electromyographic recording

The time (latency) between the onset of the external intercostal muscle (EIC EMG) and the electromyographic activity of external anal sphincter (EAS EMG), during a cough effort.

次要结局

  • Duration (time)(1 day: During electromyographic recording)
  • Maximum(1 day: During electromyographic recording)
  • Area under the curve(1 day: During electromyographic recording)

研究者

发起方
Pierre and Marie Curie University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Gérard Amarenco

Head of Neuro-Urology department, Tenon hospital

Pierre and Marie Curie University

研究点 (1)

Loading locations...

相似试验