Effects of Probiotics on Streptococcus Mutans ve Lactobacillus Spp
- Conditions
- ProbioticsTooth DecayStreptococcus Mutans
- Interventions
- Dietary Supplement: Probiotic use
- Registration Number
- NCT05859646
- Lead Sponsor
- Didem Sakaryali Uyar
- Brief Summary
To evaluate the change of S. mutans and Lactobacillus spp. counts after all dental treatments were completed under general anesthesia and compare the groups in case of using probiotics and not using probiotics with the time for 6-months follow-up period.
- Detailed Description
Fifthy-eight pediatric patients without any systemical diseases whose dental treatments were completed under general anesthesia were included in the study. The study was carried out as two-groups; Group A: Patients who started using probiotics after general anesthesia and Group B: Patients who did not use probiotics after general anesthesia. The counts of S. mutans and Lactobacillus spp. were determined by quantitative polymerase chain reaction (qPCR) by analysis of saliva samples taken from all patients on the day before the general anesthesia (T0), at 1-month (T1), 3-month (T2) and 6-month (T3) follow-up periods. The statistical significance level was accepted as p\<0.05.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 58
- Every included child had at least 8 tooth with caries.
- Patients who would not be able to give saliva samples due to high anxiety or lack of saliva were not included in this study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Probiotics Probiotic use Group A-Probiotics group: Patients who started using probiotic drops after general anesthesia procedure
- Primary Outcome Measures
Name Time Method S mutans count 6 month CFU
Lactobacillus spp count 6 month CFU
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Başkent University
🇹🇷Ankara, Cankaya, Turkey