Evaluation of Streptococcus Mutans and Lactobacillus Species Due to Probiotic Use in Oral Flora
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 58
- 试验地点
- 2
- 主要终点
- Lactobacillus spp count
研究概览
简要总结
To evaluate the change of S. mutans and Lactobacillus spp. counts after all dental treatments were completed under general anesthesia and compare the groups in case of using probiotics and not using probiotics with the time for 6-months follow-up period.
详细描述
Fifthy-eight pediatric patients without any systemical diseases whose dental treatments were completed under general anesthesia were included in the study. The study was carried out as two-groups; Group A: Patients who started using probiotics after general anesthesia and Group B: Patients who did not use probiotics after general anesthesia. The counts of S. mutans and Lactobacillus spp. were determined by quantitative polymerase chain reaction (qPCR) by analysis of saliva samples taken from all patients on the day before the general anesthesia (T0), at 1-month (T1), 3-month (T2) and 6-month (T3) follow-up periods. The statistical significance level was accepted as p<0.05.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
盲法说明
The outcome assessment was performed by a different researcher who was unaware of the group distributions in which patients were included.
入排标准
- 年龄范围
- 2 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Every included child had at least 8 tooth with caries.
排除标准
- •Patients who would not be able to give saliva samples due to high anxiety or lack of saliva were not included in this study.
结局指标
主要结局
Lactobacillus spp count
时间窗: 6 month
CFU
S mutans count
时间窗: 6 month
CFU
次要结局
未报告次要终点
研究者
Didem Sakaryali Uyar
Asst. Prof. Dr.
Baskent University