JPRN-jRCTs041200034已完成1 期
Safety assessment of nicotinamide mononucleotide (NMN) for humans
akagawa Takashi0 个研究点目标入组 30 人开始时间: 2020年7月20日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
Healthy volunteers were treated with NMN or placebo for 12 weeks, and physiological and blood tests were performed to confirm safety. NAD and related metabolites in whole blood were also measured. 12 weeks of oral administration of NMN resulted in no abnormalities in physiological and blood tests and no apparent adverse effects. The concentration of NAD in whole blood increased significantly after NMN administration. A significant increase in NAMN concentration was also observed.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 20age old 至 <= 65age old（—）
- 性别
- All
入选标准
- •1. Healthy Japanese volunteer with age between 20 and 65
- •2. Qualified person judged by medical doctor based on the results of clinical laboratory test:
- •TG, LDL-cholesterol, fasting glucose, HbA1c, AST, ALT, gamma-GTP, Serum amylase, Creatinine
排除标准
- •1.Person with past treatment history of malignant tumor, heart failure, or myocardial infarction.
- •2.Person currently under treatment for atrial fibrillation, arrhythmia, hepatic dysfunction, renal dysfunction, cerebrovascular disorder, rheumatism, diabetes, dyslipidemia, hypertension, or other chronic diseases.
- •3.Person with medication (including Kampo medicine).
- •4.Person with allergy against medicine or the test food
- •5.Pregnant, unwilling to practice contraception during the study, or lactating female
- •6.Person who is not judged as not qualified by the medical doctor.
研究者
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