Calprotectin I in Serum as a Diagnostic Marker of Pneumonia in Patients Hospitalised With Acute COPD Exacerbation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 113
- 试验地点
- 1
- 主要终点
- Calprotectin concentration in serum
研究概览
简要总结
Lower respiratory tract infection is the most common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Patients diagnosed with pneumonia in addition to an AECOPD experience more severe clinical and laboratory disease manifestations, increase in-hospital morbidity and worse outcome. Clinicians have sought for new biomarkers that together with clinical assessments can improve the diagnostic accuracy of pneumonia in patients with AECOPD.The aim of the present study is to compare the accuracy of calprotectin with procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count (WBC).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •clinically confirmed acute exacerbation of chronic obstructive pulmonary disorder (AECOPD)
- •COPD diagnosis previously confirmed by spirometry according to the GOLD criteria.
排除标准
- •known malignant disease
- •bronchiectasis
- •chronic bacterial colonisation of the airways
- •treatment with an immunosuppressive drug or long-term treatment with antibiotics.
- •not examined with a chest X-ray at admission
结局指标
主要结局
Calprotectin concentration in serum
时间窗: Change in serum concentration from baseline to 48 hours
ELISA-kit (MRP8/14 ELISA)
次要结局
未报告次要终点