Phase II study of induction therapy: S-1 and cisplatin with concurrent radiation for patient with stage IIA-IIIA locally advanced non-small cell lung cancer.
- Conditions
- on-small cell lung cancer
- Registration Number
- JPRN-UMIN000008205
- Lead Sponsor
- Division of Surgical Oncology, Nagasaki Graduate School of Biomedical Sciences
- Brief Summary
The actual number of patients enrolled was 23, and 20 were able to complete the surgery. Three patients dropped out because of patient refusal, leukopenia, or ALK-positive PD. 12 of the 20 patients had SD, and 8 had PR. All surgeries were complete resections, including lobectomies or more, two lobectomies in two patients, and combined resections of the chest wall in six patients. Postoperative pathology revealed a down stage in 13 patients, and the tumor component disappeared in 4 patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 23
Not provided
1)Stage II without lymph node metastasis, stage IIIA with single N2, and stage IIIB with N3beta or gamma 2)Patients with a history of drug hypersensitivity 3)Patients with administration of phenitoin or potassiun warfarin 4)Patients with administration of flucytosine 5)Active infection 6)Active ulcer in digestive tract 7)Serious nonsurgical complications 8)Diarreha 9)Pregnant
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Completion rate for the schedule
- Secondary Outcome Measures
Name Time Method Safety, 3-yr and 5-yr survival rate,3-yr and 5-yr relapse free survival rate.