Dutch Intraventricular Thrombolysis in Cerebral Haemorrhage study

Completed

• Conditions: Intraventricular haemorrhage, intracerebral haemorrhage; Circulatory System; Intracerebral haemorrhage

• Registration Number: ISRCTN19105863
• Lead Sponsor: Academic Medical Centre (AMC) (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01-09
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

1. Age >18 years
2. IVH caused by extension of spontaneous ICH confirmed by computed tomography (CT) scan
3. Glasgow Coma Score on admission of <14
4. Able to include patients within 48 hours after ICH onset
5. Historical mRankin of 0 or 1

Exclusion Criteria

1. IVH caused by aneurysm or arteriovenous malformation as seen on CT-scan
2. Only sedimentation of blood in the lateral ventricles
3. Infratentorial bleeding
4. Evacuation of parenchymal hematoma is deemed necessary
5. Clotting disorder
6. Pregnancy
7. Epileptic seizure at onset
8. Absence of brain stem reflexes on admission
9. If death appears imminent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Poor outcome at three months (mRankin scale and GOS).

Secondary Outcome Measures

Name	Time	Method
1. Drain dependency at 3 months<br>2. Amsterdam Linear Disability Scale score at 3 months<br>3. Intraventricular or parenchymal bleeding complications<br>4. Ventriculitis