Efficacy and Safety of Oral Vitamin D supplementation on pulmonary function parameters assessed by forced oscillation technique in children with bronchial asthma: A pilot, double blind, randomized trial ? - NA

All India Institute of Medical Sciences0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年3月4日

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•Patients with bronchial asthma diagnosed based on GINA 2023 criteria or ERS/ATS criteria
•Inclusion criteria
•A) Children with newly diagnosed Bronchial Asthma based on the following criteria.
•1) Clinical feature suggestive of bronchial asthma as per GINA 2023
•2) Clinical feature and or bronchodilator responsiveness based on FOT/Spirometry as per ERS/ATS criteria
•B) Children who have been treated for Bronchial Asthma previously will be eligible for inclusion if they are off maintenance therapy (i.e Inhaled Corticosteroids) since last 3 months.
•Stratification of study population:
•A)Newly diagnosed Vs Previously diagnosed

•Children who received systemic corticosteroids (any preparation, any dose, any route) for more than 3 weeks in preceding 6 months
•Immunosuppressed states including diabetes mellitus, chronic renal failure, chronic liver failure and others
•Children with rickets, skeletal chest deformity, bronchopulmonary dysplasia, coexisting primary parenchymal pulmonary disease (e.g., cystic fibrosis, bronchiectasis), known case of vitamin ?D deficiency or parathyroid disease, and those received vitamin D or calcium supplements in past 3 months.
•Underlying disease (e.g., lupus erythematosus, IgA nephropathy, amyloidosis)
•Evidence of steroid toxicity: Cataract, glaucoma, body mass index >30 or height <-3 SD of that expected

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