A randomised, double-blind, placebo-controlled study on the impact of doxycycline on aversive memory in healthy individuals
- Conditions
- healthy subjects
- Registration Number
- DRKS00017037
- Lead Sponsor
- Department of Psychiatry, Psychotherapy, Psychosomatics, University of Zurich
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 560
Informed Consent as documented by signature
- Age 18 – 40 years
• Allergy to doxycycline or to any other ingredient in the named drugs
• Use of any drugs in the 2 weeks prior to the study with the exception of contraceptive drugs and incidental use of NSARs or paracetamol
• Women who are pregnant or breast feeding,
• Intention to become pregnant during the course of the study,
• Lack of safe contraception, defined as: Female participants of childbearing potential, not using and not willing to continue using a medically reliable method of contraception for the entire study duration
• Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.)
• Any history of psychiatric, neurological, addiction, or systemic/rheumatic disease
• Known or suspected non-compliance, drug or alcohol abuse
• Inability to follow the procedures of the study, e.g. due to language problems
• Participation in another study with investigational drug within 30 days preceding and during the present study,
• Previous enrolment into the current study,
• Members of the study team and their family members and dependants
• Regular work in a medical profession
• Life time history of being a victim of interpersonal violence or other potentially traumatic experience, or close relative of a person with such history
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary endpoints are updated prompt to the start of a new experiment.<br>Experiment 1 and 2:<br>Fear-potentiated startle, measured via eyeblink EMG of the M. orbicularis oculi and quantified according to Khemka et al. (2017)<br>Detailed analysis plan: https://osf.io/6kj5u/.<br><br><br>Experiment 5:<br>Quantity and distress of intrusion in an intrusion diary during one week following the trauma film
- Secondary Outcome Measures
Name Time Method Experiment 1 und 2:<br>SCR (skin conductance response), respiration amplitude, heart period measured with ECG (Electrocardiogram), pupil reaction, neuropsychological tests (e.g. VLM-T), questionnaires (STAI).<br><br>Experiment 5:<br>Questionnaires (e.g. STAI, BIS-BAS), SCR (skin conductance response), respiration amplitude, heart period measured with ECG (Electrocardiogram), neuropsychological tests (e.g. VLM-T).