Effects of Long-term Exercise on Various Parameters in Heavy Drinkers
- Conditions
- Alcohol AbuseHeavy DrinkingAlcohol Use Disorder
- Interventions
- Behavioral: Exercise training program
- Registration Number
- NCT02664766
- Lead Sponsor
- University of Thessaly
- Brief Summary
The purpose of this research is to examine the effects of long-term aerobic exercise of moderate intensity on psychological, physiological, biochemical, physiological and alcohol-related parameters in heavy drinkers, in order to investigate possible biochemical mechanisms by which exercise may be a healthy alternative to alcohol abuse.
- Detailed Description
The mechanism of incentives that lead people to unhealthy habits such as excessive alcohol consumption is not only social, personal, and psychological, but also associated with neurochemical and neurobiological mechanisms.
Several programs have been developed to stop excessive drinking, but the success rates are small, while the relapse rates are very high, reaching up to 90%. Although there is some evidence for the beneficial effects of exercise on alcohol use disorders, research is limited. The present study investigates whether exercise can act as adjunct therapy for alcohol abuse cessation.
One of the basic assumptions is that the appropriate form of exercise in alcoholics will contribute to the secretion of beta-endorphin, which in combination with psychological pleasure, vitality, change of mood, reduced stress, increased confidence, and the shift of attention will help people to follow healthy lifestyles and abhor alcohol.
The research project is divided in three phases. In the first phase, the effect of acute exercise in critical psychological, physiological, biochemical and alcohol-related parameters associated with excessive alcohol consumption will be examined. In the second phase (current study), a long-term exercise program in conjunction with psychological support strategies aimed at alcohol abuse cessation will be developed, implemented and evaluated. Finally, in the third phase, based on the results of the previous phases, awareness programs in adolescent and adult populations will be designed and implemented as well as the dissemination of results and evaluation of the project will take place.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
- Men drinking >14 drinks/week or >4 drinks/occasion; Women drinking >7 drinks/week or >4 drinks/occasion (1 drink = 14 grams of pure alcohol; definition of the NIAAA for drinking at low risk for developing an AUD; NIAAA, 2014)
- Individuals drinking 5 or more drinks on the same occasion on each of 5 or more days in the past 30 days (1 drink = 14 grams of pure alcohol; definition of the Substance Abuse and Mental Health Services Administration for heavy drinking; NIAAA, 2014) Alcohol Use Disorders Identification Test (AUDIT) score>8
- Medical conditions or medication use that would preclude participation in aerobic exercise
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Exercise training program Exercise training program Supervised 8-week exercise training program. Aerobic exercise (walking, jogging) of increasing duration at 50-60% HRR, at least two sessions per week.
- Primary Outcome Measures
Name Time Method Changes in alcohol consumption (grams of alcohol consumed weekly) At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Self-recorded
Changes in Beta-endorphin levels At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Measured by radioimmunoassay (RIA)
- Secondary Outcome Measures
Name Time Method Adrenocorticotrophic hormone (ACTH) At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Measured by radioimmunoassay (RIA)
Urge to drink At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention According to questionnaire
Cortisol At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Measured by radioimmunoassay (RIA)
Catecholamines (epinephrine, norepinephrine, dopamine) At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Measured by radioimmunoassay (RIA)
C-reactive protein (CRP) At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Semi-quantitative estimation with CRP Latex test kit
Complete blood count At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Autoanalyzer Autoanalyzer Autoanalyzer
Lactic acid At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Measured using photometry
Erythrocyte sedimentation rate (ESR) At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Wintrobe Method
γ-Glutamyltransferase (GGT) At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Measured with commercial kit
Aspartate Aminotransferase (AST) At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Measured with commercial kit
Alanine Aminotransferase (ALT) At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Measured with commercial kit
Sit and reach flexibility test for the hamstrings muscles and lower back At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Each participant sits on the floor with legs stretched out straight ahead, reaches out and holds that position for at 1-2 seconds while the distance is recorded.
Grip strength At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Handgrip strength test
Number of push-ups performed in one minute At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention Number of sit-ups performed until exhaustion At baseline and at 4th week of control condition; at baseline (before intervention), at 4th week and at 8th week of intervention