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Clinical Trials/NCT05410912
NCT05410912Active, not recruitingNot Applicable

Varicose Vein in Patients Under the Age of 40

First Affiliated Hospital of Zhejiang University1 site in 1 country168 target enrollmentStarted: January 1, 2021Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Active, not recruiting
Sponsor
Enrollment
168
Locations
1
Primary Endpoint
Postoperative varicose veins sequelae

Study Overview

Brief Summary

Varicose veins are a result of valvular insufficiency and presented with twisted, enlarged veins. They not only cause cosmetic concerns but also lead to limb edema, skin pigmentation/lipodermatosclerosis, and even venous ulcers. This disease affects a large percentage of the population. Although there have been several researches on the risk factors for varicose veins and the outcomes of alternative therapies , there is currently limited data focusing on varicose veins in young patients. In this case-control study, we wanted to assess the risk factors for varicose veins in patients under the age of 40, as well as their long-term results of surgery.

Study Design

Study Type
Observational
Observational Model
Case Control
Time Perspective
Retrospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • great saphenous varicose veins (GSVV) with saphenous vein reflux >0.5s.
  • lower extremity venography excluding iliac vein compression;
  • treated by great saphenous vein stripping and ambulatory phlebectomy.
  • the patient had a minimum follow-up of five years.

Exclusion Criteria

  • secondary varicose veins (defined as varicose veins caused by deep vein thrombosis, iliac venous compression or venous injury etc.);
  • small saphenous veins;
  • treated by endovenous ablation/laser or sclerotherapy alone.

Outcomes

Primary Outcomes

Postoperative varicose veins sequelae

Time Frame: Five years after surgery.

The sequelae of the varicose vein were assessed by Venous Clinical Severity Score (VCSS). The total score is 0\~30. The higher scores mean a worse outcome.

Postoperative quality of life

Time Frame: Five years after surgery.

Quality of life was assessed by the Aberdeen Varicose Vein Questionnaire (AVVQ). The total score is 1\~100. The higher scores mean a worse outcome.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
First Affiliated Hospital of Zhejiang University
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Ziheng Wu, MD

Associated chief physician

First Affiliated Hospital of Zhejiang University

Study Sites (1)

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