Post-neurosurgical Respiratory Muscle Dysfunction
- Conditions
- Pulmonary ComplicationDiaphragm IssuesNeurosurgery
- Interventions
- Diagnostic Test: Maximum inspiratory/Expiratory manoeuvre for patients can follow the order
- Registration Number
- NCT05951114
- Lead Sponsor
- Beijing Sanbo Brain Hospital
- Brief Summary
Respiratory muscle dysfunction may contribute to the development of postoperative pulmonary complications. However, it prevalence in patients receiving neurosurgery is largely unknown. Therefore, in present study, respiratory muscle function (measured by the ultrasound) and their correlation with the post-operative pulmonary complications will be analyzed.
- Detailed Description
Postoperative pulmonary complications is common in patients receiving neurosurgery, and is associated with hospitalization cost and mortality. Respiratory muscle dysfunction is an important cause postoperative pulmonary complications, however, it's prevalence in patients receiving neurosurgery is unclear.
The diaphragm and abdominal expiratory muscles are the main inspiratory and expiratory driving muscles. Ultrasound can assess the function and morphology of these muscles invasively and in realtime. Studies has demonstrated their feasibility and repeatability in realtime monitoring of respiratory muscles.
In this study, our primary aim is to assess the respiratory muscle function after neurosurgery, and the correlation between diaphragm and expiratory muscle function. Our secondary aims including the correlation between the brain injury and the respiratory muscle function, and the impact of post-operative respiratory muscle dysfunction on the pulmonary complications.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
- Informed consent
- First elective operation during hospitalization
- ASA<3
- Brain stem and spinal spine lesions
- Preoperative chest imaging findings were abnormal
- Mechanical ventilation was required before surgery
- Clinical or radiological evidence of preoperative misaspiration
- History of neurosurgery in the last 6 months
- A history of neuromuscular disease
- BMI≥35kg/m2
- Pregnant women
- Skin lesions detected by ultrasound
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with diaphragm weakness Maximum inspiratory/Expiratory manoeuvre for patients can follow the order Diaphragm weakness will be defined as thickening fraction \<=20 % at the time of extubation Patients without diaphragm weakness Maximum inspiratory/Expiratory manoeuvre for patients can follow the order Diaphragm thickening fraction \>20 % at the time of extubation
- Primary Outcome Measures
Name Time Method Incidence of diaphragm dysfunction after neurosurgery Within 24 hours after the completion of surgery The diaphragm dysfunction is defined as the thickening fraction \< 20% under the maximum inspiration
- Secondary Outcome Measures
Name Time Method The correlation between the level of inflammation maker ILs and the diaphragm function Within 24 hours after the completion of surgery The level of ILs are measured in the blood sample within 24 hours after surgery
The thickening fraction of expiratory muscles after surgery Within 24 hours after the completion of surgery the thickening fraction of expiratory muscle is measured under the maximum expiration maneuver
The length of ICU stay Through study completion, an average of 1 month The length of ICU stay is counted by day
The correlation between the level of NSE and the diaphragm function Within 24 hours after the completion of surgery The level of NSE is measured in the blood sample within 24 hours after surgery
The incidence of postoperative pulmonary complication Through study completion, an average of 1 month The postoperative pulmonary complication is defined as when patient has developed one or more complications including pneumonia, atelectasis, pulmonary edema, pulmonary embolism, or respiratory failure
Hospital mortality Through study completion, an average of 1 month The hospital mortality is recorded at the time of discharge
The length of hospital stay Through study completion, an average of 1 month The length of hospital stay is counted by day
Duration of mechanical ventilation Through study completion, an average of 1 month The duration of mechanical ventilation is counted by hours
The correlation between the level of inflammation maker TNF-alpha and the diaphragm function Within 24 hours after the completion of surgery The level of TNF-alpha is measured in the blood sample within 24 hours after surgery
Trial Locations
- Locations (1)
Beijing Sanbo Brain Hospital, Capital Medical University
🇨🇳Beijing, Beijing, China